下肢动脉硬化性闭塞药物涂层球囊治疗后再狭窄的危险因素  

Risk factors for restenosis after drug-coated balloon therapy in lower extremity arteriosclerosis occlusion

作　　者：郭旭 曹水英 张冬燕 闫鹤 Guo Xu;Cao Shuiying;Zhang Dongyan;Yan He(Department of Interventional Medicine,Beijing Chao-Yang Hospital,Capital Medical University,Beijing 100043,China)

机构地区：[1]首都医科大学附属北京朝阳医院介入医学科,北京100043

出　　处：《血管与腔内血管外科杂志》2024年第5期529-532,550,共5页Journal of Vascular and Endovascular Surgery

摘　　要：目的探讨下肢动脉硬化性闭塞药物涂层球囊治疗后再狭窄的危险因素。方法收集2021年1月至2022年6月于首都医科大学附属北京朝阳医院接受药物涂层球囊治疗的96例下肢动脉硬化性闭塞患者的临床资料,根据治疗后1年随访期间是否发生再狭窄将患者分为再狭窄组(n=31)和对照组(n=65)。比较两组患者的临床特征、介入手术相关信息以及术后随访期间用药情况,采用多因素Logistic回归模型分析下肢动脉硬化性闭塞药物涂层球囊治疗后再狭窄的危险因素。结果再狭窄组患者的年龄大于对照组患者,吸烟、糖尿病及二次介入手术的比例均高于对照组患者(P﹤0.05)。多因素分析结果显示,老年(年龄≥65岁)、糖尿病、吸烟及二次介入手术均为下肢动脉硬化性闭塞药物涂层球囊治疗后再狭窄的独立危险因素(P﹤0.05)。结论多种因素与下肢动脉硬化性闭塞药物涂层球囊治疗后再狭窄密切相关,包括年龄、糖尿病、吸烟及靶病变二次介入手术,临床中应据此筛查术前高危患者,并对此类患者强化药物治疗和术后随访。Objective To investigate the risk factors of restenosis after drug-coated balloon therapy for lower extremity arteriosclerosis occlusion.Method The clinical data of 96 patients with lower extremity arteriosclerosis occlusion who received drug coated balloon therapy at the Beijing Chao-Yang Hospital,Capital Medical University from January 2021 to June 2023 were collected.All patients were divide into restenosis group(n=31)and control group(n=65)based on the occurrence of restenosis during 1-year follow-up.The clinical characteristics,interventional surgery related information,medication use during postoperative follow-up between the two groups of patients were compared.The risk factors of restenosis after drug-coated balloon therapy for lower extremity arteriosclerosis occlusion were analyzed by multivariate Logistic regression model.Result The age of patients in the restenosis group was older than that in the control group,the proportion of smoking,diabetes and secondary interventional surgery were higher than those in the control group(P<0.05).The multivariate analysis showed that old age(≥65 years old),diabetes,smoking,and secondary interventional surgery were independent risk factors for restenosis after drug coated balloon therapy of lower extremity atherosclerotic occlusion.Conclusion Multiple factors are closely related to restenosis after drug coated balloon therapy for lower extremity arteriosclerotic occlusion,including age,diabetes,smoking,and secondary interventional surgery for target lesions.In clinical practice,high-risk patients before surgery should be screened accordingly,and drug treatment and postoperative follow-up should be strengthened for such patients.

关 键 词：下肢动脉硬化性闭塞 药物涂层球囊 再狭窄 危险因素 

分 类 号：R543[医药卫生—心血管疾病]