硝苯地平控释片联合拉贝洛尔治疗妊娠高血压患者的疗效观察  

Efficacy of combined use of nifedipine controlled release tablets andlabetalol in treating patients with pregnancy-induced hypertension

作　　者：周科秀 牟燕琳[2] 王鑫灵 马文鑫 罗红艳 ZHOU Kexiu;MOU Yanlin;WANG Xinling;MA Wenxin;LUO Hongyan(Department of Obstetrics,The Third People′s Hospital of Chengdu,Chengdu 610043,China;Department of Obstetrics and Gynecology,The Third People′s Hospital of Chengdu,Chengdu 610043,China)

机构地区：[1]成都市第三人民医院产科,四川成都610043 [2]成都市第三人民医院妇产科,四川成都610043

出　　处：《西部医学》2024年第7期1037-1041,共5页Medical Journal of West China

基　　金：四川省卫生健康委科研课题(18PJ060)。

摘　　要：目的探讨联合使用硝苯地平控释片和拉贝洛尔治疗妊娠高血压患者的疗效。方法选取2019年1月—2022年1月我院收治的妊娠高血压患者156例,采用随机数字表法分为对照组(硝苯地平控释片治疗)和观察组(硝苯地平控释片+拉贝洛尔治疗),每组78例,治疗30 d。比较两组治疗疗效,治疗前后血压、血液流变学(全血、血细胞比容与血浆黏度)及血流动力学[血流灌注指数(PI)、动脉阻力指数(RI)及脐动脉收缩(S)/舒张末期血流速度(D)比值(S/D)]变化,血清因子[高敏C反应蛋白(hs-CRP)、前列腺素E2(PGE2)和血清脂联素(APN)]表达水平,随访两组母婴结局,统计两组治疗期间不良反应情况。结果观察组治疗总有效率达93.59%,显著高于对照组的83.33%(P<0.05);治疗后,两组舒张压和收缩压均较治疗前降低,且观察组舒张压和收缩压显著低于对照组,两组以上指标治疗前后差值比较具有统计学意义(均P<0.05);治疗后,两组血液流变学指标和动力学指标均较治疗前降低,且观察组显著低于对照组,两组以上指标治疗前后差值比较具有统计学意义(均P<0.05);治疗后,两组hs-CRP均较治疗前降低,PGE2和APN均较治疗前升高,且观察组hs-CRP显著低于对照组,PGE2和APN显著高于对照组,两组以上指标治疗前后差值比较具有统计学意义(均P<0.05);观察组剖宫产发生率显著低于对照组(P<0.05)。结论妊娠高血压患者使用硝苯地平控释片和拉贝洛尔联合治疗,能有效控制患者血压,提高血液流变学和动力学指标,改善母婴结局。Objective To observe the efficacy of nifedipine controlled release tablets combined with labetalol in the treatment of patients with pregnancy-induced hypertension.Methods 156 patients with pregnancy-induced hypertesion admitted to the hospital from January 2019 to January 2022 were selected and divided into control group(n=78,nifedipine controlled release tablets)and observation group(n=78,nifedipine controlled release tablets+labetalol)by simple randomization method,and both groups were treated for 30 days.The therapeutic efficacy,and blood pressure,hemorheology and hemodynamics changes and expression levels of serum factors before and after treatment were compared between the two groups.Maternal-infant outcomes were followed up in the two groups,and adverse reactions during treatment were statistically analyzed.Results The total effective rate in observation group was 93.59%,which was significantly higher than 83.33%in control group(P<0.05).After treatment,the diastolic blood pressure and systolic blood pressure of the two groups were reduced compared with those before treatment(P<0.05),and the diastolic blood pressure and systolic blood pressure were significantly lower in observation group compared to control group(P<0.05),and the differences between the two groups were statistically significant(P<0.05).The hemorheological indicators and hemodynamic indicators in both groups were decreased after treatment compared with those before treatment(P<0.05),and the above indicators in observation group were significantly lower than those in control group(P<0.05),and the differences of the above indicators between the two groups were statistically significant(P<0.05).After treatment,the hs-CRP in the two groups was declined(P<0.05)while the PGE2 and APN were risen compared to before treatment(P<0.05),and hs-CRP in observation group was significantly lower(P<0.05)while PGE2 and APN were significantly higher than those in control group(P<0.05),and the differences between both groups were statistically significant(P<0.0

关 键 词：妊娠高血压 硝苯地平 拉贝洛尔 疗效 母婴结局 

分 类 号：R714.252[医药卫生—妇产科学]