SAA、IL-6、C3、C4联合检测对SLE患者的诊断价值  

Diagnostic Value of Combined Detection of SAA, IL-6, C3 and C4 in SLE Patients

作　　者：梁敏敏 邹光美 杨小兰[2] 吴声楹 吴博文[1] LIANG Min-min;ZOU Guang-mei;YANG Xiao-lan;WU Sheng-ying;WU Bo-wen(Department of Clinical Laboratory,,the First People's Hospital of Yulin,Yulin 537000,Guangxi,China;Department of Rheumatology and Immunology,the First People's Hospital of Yulin,Yulin 537000,Guangxi,China)

机构地区：[1]玉林市第一人民医院检验科,广西玉林537000 [2]玉林市第一人民医院风湿免疫科,广西玉林537000

出　　处：《医学信息》2024年第14期96-99,共4页Journal of Medical Information

基　　金：玉林市科学研究与技术开发计划课题(编号:玉市科20204402);广西壮族自治区卫生健康委员会自筹经费科研课题(编号:Z20211083)。

摘　　要：目的 探讨SAA、IL-6、C3、C4与SLE患者的疾病相关性,分析危险因素。方法 选取2020年10月-2023年5月在玉林市第一人民医院就诊SLE患者110例,以及同期健康体检者80例作为研究对象,比较两组的SAA、IL-6、C3、C4水平,以及指标检测的诊断价值。结果 与对照组比较,SLE组SAA、IL-6水平均升高,而SLE组C3、C4水平均降低,差异有统计学意义(P<0.05)。ROC曲线分析结果显示,单指标检测时C3的AUC最大(AUC=0.916);而联合检测时SAA+IL-6的AUC最大(AUC=0.920)。二元Logistic回归分析显示,SAA、IL-6是SLE患者的危险因素,而C3则是SLE患者保护因素。Spearman相关分析显示,SAA与IL-6呈正相关;SAA和IL-6分别与C3、C4呈负相关。结论 联合SAA、IL-6、C3、C4检测及综合评估相关性,对SLE的诊疗及预后有重要的参考价值。Objective To investigate the correlation and risk factors of SAA,IL-6,C3 and C4 in patients with SLE.Methods From October 2020 to May 2023,110 patients with SLE inthe First People's Hospital of Yulin and 80 healthy people in the same period were selected as the research objects.The levels of SAA,IL-6,C3 and C4 in the two groups were compared,as well as the diagnostic value of index detection.Results Compared with the control group,the levels of SAA,IL-6 in the SLE group were increased,while the levels of C3 and C4 in the SLE group were decreased,and the differences were statistically significant(P<0.05).The results of ROC curve analysis showed that the AUC of C3 was the largest(AUC=0.916).The AUC of SAA+IL-6 was the largest(AUC=0.920).Binary Logistic regression analysis showed that SAA and IL-6 were risk factors for SLE patients,while C3 was a protective factor for SLE patients.Spearman correlation analysis showed that SAA was positively correlated with IL-6,SAA and IL-6 were negatively correlated with C3 and C4,respectively.Conclusion The combination of SAA,IL-6,C3,C4 detection and comprehensive evaluation of the correlation has important reference value for the diagnosis,treatment and prognosis of SLE.

关 键 词：血清淀粉样蛋白A 白介素6 补体 系统性红斑狼疮 

分 类 号：R593.241[医药卫生—内科学] R446.6[医药卫生—临床医学]