盐酸纳布啡及酮咯酸氨丁三醇对颅脑外伤出血患者镇痛效果及血流动力学的影响  

Effect of Nalbuphine Hydrochloride and Ketorolac Tromethamine on Analgesic Effectand Hemodynamics in Patients with Craniocerebral Trauma Hemorrhage

作　　者：芦孙俊 LU Sun-jun(Department of Brain Surgery,Guangxin District Hospital of Traditional Chinese Medicine,Shangrao 334109,Jiangxi,China)

机构地区：[1]上饶市广信区中医院脑外科,江西上饶334109

出　　处：《医学信息》2024年第14期115-118,共4页Journal of Medical Information

摘　　要：目的 研究盐酸纳布啡及酮咯酸氨丁三醇对颅脑外伤出血患者镇痛效果及血流动力学的影响。方法 选取上饶市广信区中医院于2020年6月-2023年6月收治的60例颅脑外伤出血患者为研究对象,依据随机数字表法分为对照组(30例)与观察组(30例)。对照组给予酮咯酸氨丁三醇镇痛,观察组则采用盐酸纳布啡联合酮咯酸氨丁三醇镇痛,比较两组镇痛起效时间、Ricker镇静-躁动评分(SAS)、镇痛效果[视觉模拟评分(VAS)]、血流动力学[心率(HR)、平均动脉压(MAP)、呼吸频率(RR)]及不良反应发生情况。结果 观察组镇痛起效时间短于对照组,SAS评分小于对照组(P<0.05);观察组用药后30 min、用药后6 h的VAS评分低于对照组(P<0.05);两组用药后30 min的HR、MAP、RR指标均低于用药前,且观察组HR、MAP、RR指标低于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 盐酸纳布啡联合酮咯酸氨丁三醇在颅脑外伤出血患者中具有良好镇痛作用,其起效快、效果好,可稳定患者血流动力学水平,且具有良好用药安全性。Objective To study the effect of nalbuphine hydrochloride and ketorolac tromethamine on analgesia and hemodynamics in patients with craniocerebral trauma hemorrhage.Methods A total of 60 patients with craniocerebral trauma hemorrhage admitted to Guangxin District Hospital of Traditional Chinese Medicine of Shangrao City from June 2020 to June 2023 were selected as the research objects.According to the random number table method,they were divided into control group(30 patients)and observation group(30 patients).The control group was given ketorolac tromethamine for analgesia,while the observation group was given nalbuphine hydrochloride combined with ketorolac tromethamine for analgesia.The onset time of analgesia,Ricker Sedation-agitation Scale(SAS)score,analgesic effect[Visual Analogue Scale(VAS)score],hemodynamics[heart rate(HR),mean arterial pressure(MAP),respiratory rate(RR)]and adverse reactions were compared between the two groups.Results The onset time of analgesia in the observation group was shorter than that in the control group,and the SAS score was lower than that in the control group(P<0.05).The VAS scores of the observation group at 30 min and 6 h after treatment were lower than those of the control group(P<0.05).The HR,MAP and RR indexes of the two groups at 30 min after medication were lower than those before medication,and the HR,MAP and RR indexes of the observation group were lower than those of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Nalbuphine hydrochloride combined with ketorolac tromethamine has a good analgesic effect in patients with craniocerebral trauma hemorrhage.It has a fast onset and good effect,can stabilize the hemodynamic level of patients,with good drug safety.

关 键 词：颅脑外伤出血 盐酸纳布啡 酮咯酸氨丁三醇 镇痛效果 血流动力学 

分 类 号：R651.15[医药卫生—外科学]