老年患者应用艾司氯胺酮麻醉的临床研究进展  

Progress in clinical research of esketamine anesthesia in elderly patients

作　　者：蓝金辛 李森 何俊冰 杨铎 张欢楷[2] 张隆盛 Lan Jinxin;Li Sen;He Junbing;Yang Duo;Zhang Huankai;Zhang Longsheng(First Clinical Medical College,Guangdong Medical University,Zhanjiang 524023,Guangdong Province,China;Department of Anesthesiology,Jieyang People′s Hospital,Jieyang 522000,Guangdong Province,China)

机构地区：[1]广东医科大学第一临床医学院,广东湛江524023 [2]揭阳市人民医院麻醉科,广东揭阳522000

出　　处：《中华老年多器官疾病杂志》2024年第7期549-552,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：广东省基础与应用基础研究基金项目(2022A1515012413);广东省医学科学技术研究基金(B2022294);广东省中医药局面上科研项目(20191409)。

摘　　要：随着中国经济的发展,老龄化社会问题日益突出,如何在保证老年患者围术期安全的前提下科学选择麻醉药物成为麻醉医师急需解决的问题之一。老年人往往各系统功能生理性降低,重要器官代偿能力减弱。艾司氯胺酮作为氯胺酮的右旋异构体,通过非竞争性抑制N-甲基-D-天冬氨酸受体,产生良好的镇静、镇痛及抗抑郁等作用,同时对神经系统、循环系统及呼吸系统起到良好的保护作用,在老年患者麻醉中有较好的应用前景。本文就艾司氯胺酮在老年患者麻醉中应用的研究进展进行综述。In the context of its economy,the problem of aging society has become increasingly prominent in China.How to scientifically select anesthetics with consideration of ensuring the perioperative safety of the elderly patients has become one of the most urgent problems for anesthesiologists.The elderly usually experience declining physiological function of various systems and weakening compensatory ability of important organs.Esketamine,the dextrorotatory isomer of ketamine,produces good sedative,analgesic,and antidepressant effects by non-competitive inhibition of N-methyl-D-aspartate receptors,with a good protective effect for the nervous,circulatory and respiratory systems.It promises a good prospect in anesthesia in the elderly patients.This article reviews the progress in clinical research of esketamine for anesthesia in the elderly patients.

关 键 词：老年人 艾司氯胺酮 围术期 麻醉 镇痛 

分 类 号：R614.2[医药卫生—麻醉学]