抗反转录病毒疗法对结核病/人体免疫缺陷病毒双重感染患者生存预后的影响  

Effect of antiretroviral therapy on survival prognosis in patients with tuberculosis/human immunodeficiency virus double infection

作　　者：艾静 王宁 孙文峰[1] AI Jing;WANG Ning;SUN Wenfeng(Department of Infectious Diseases,Fuzhou First People's Hospital,Fuzhou,Jiangxi,344000,China)

机构地区：[1]抚州市第一人民医院感染科,江西抚州344000

出　　处：《当代医学》2024年第6期27-31,共5页Contemporary Medicine

摘　　要：目的分析抗反转录病毒治疗(ART)对结核病(TB)/人体免疫缺陷病毒(HIV)双重感染患者生存预后的影响。方法选取2020年1月至2022年4月抚州市第一人民医院感染科收治的72例TB/HIV双重感染患者作为研究对象,根据是否接受ART分为ART组(n=40)与对照组(n=32)。对照组给予常规抗结核对症治疗,ART组在对照组基础上2周内给予ART方案,比较两组治疗前后CD4+T淋巴细胞数、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)水平、HIV载量及治疗后转阴率、治疗失败结局。结果治疗后1、3、6、12个月,ART组CD4+T淋巴细胞数均多于前一个时间点,对照组CD4+T淋巴细胞数均少于前一时间点,且ART组均多于对照组,差异有统计学意义(P<0.05)。治疗后,ART组IL-10、TNF-α水平均低于治疗前,对照组IL-10水平高于治疗前,且ART组IL-10、TNF-α水平均低于对照组,差异有统计学意义(P<0.05)。治疗后,ART组HIV载量少于治疗前,对照组多于治疗前,且ART组少于对照组,差异有统计学意义(P<0.05)。治疗后1、3、6、12个月,ART组转阴率均高于对照组,差异有统计学意义(P<0.05)。ART组治疗失败率为17.50%,低于对照组的100.00%,差异有统计学意义(P<0.05)。结论ART对TB/HIV双重感染患者的治疗具有积极意义,可增加CD4+T淋巴细胞数,减少HIV载量,提高转阴率,改善患者生存预后。Objective To analyze the effect of antiretroviral therapy(ART)on the survival and prognosis of patients with tuberculosis(TB)/hu-man immunodeficiency virus(HIV)double infection.Methods 72 patients with TB/HIV double infection admitted to the Infection department of Fuzhou First People's Hospital from January 2020 to April 2022 were selected as the study subjects,and they were divided into the ART group(n=40)and the control group(n=32)according to whether they received ART.The control group was given routine antituberculosis symptomatological treatment,the ART group was given ART regimen within 2 weeks on the basis of the control group.The number of CD4+T lymphocytes,interleukin-10(IL-10)and tumor necrosis factor-α(TNF-α)levels,HIV load before and after treatment,negative conversion rate and treatment failure outcome after treatment were compared between the two groups.Results After 1,3,6,and 12 months of treatment,the CD4+T lymphocyte count in the ART group were higher than that at the previous time point and the CD4+T lymphocyte count in the control group was lower than that at the previous time point,the ART group was higher than the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of IL-10 and TNF-αin the ART group were lower than before treatment,while the IL-10 levels in the control group were higher than before treatment,and the levels of IL-10 and TNF-αin the ART group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the HIV load in the ART group was lower than before treatment,while the control group was more than before treatment,and the ART group was lower than the control group,and the differences were statistically significant(P<0.05).After 1,3,6,and 12 months of treat-ment,the negative conversion rate in the ART group was higher than that in the control group,and the difference was statistically significant(P<0.05).The treatment failure rate in the ART group was 17.50%,which was

关 键 词：抗反转录病毒治疗 人体免疫缺陷病毒 结核病 双重感染 生存预后 

分 类 号：R512.91[医药卫生—内科学]