普瑞巴林联合利多卡因对带状疱疹后遗神经痛患者疼痛和血浆神经肽水平及睡眠质量的影响  

Effects of pregabalin combined with lidocaine on pain,plasma neuropeptide level and sleep quality in patients with postherpetic neuralgia

作　　者：李金虎 顾芳 孙英群 陈效曦 宋云川 LI Jinhu;GU Fang;SUN Yingqun;CHEN Xiaoxi;SONG Yunchuan(Department of Anesthesiology,Daxing District Hospital of Integrated Chinese and Western Medicine,Beijing,100076,China)

机构地区：[1]北京市大兴区中西医结合医院麻醉科,北京100076

出　　处：《当代医学》2024年第6期139-142,共4页Contemporary Medicine

摘　　要：目的探讨普瑞巴林联合利多卡因对带状疱疹后遗神经痛(PHN)患者疼痛、血浆神经肽水平及睡眠质量的影响。方法选取2020年5月至2022年4月北京市大兴区中西医结合医院收治的88例PHN患者作为研究对象,按照随机数字表法分为观察组与对照组,每组44例。对照组采用利多卡因软膏治疗,观察组在对照组基础上联合普瑞巴林治疗。比较两组临床疗效、疼痛程度、睡眠质量、生命质量、血浆神经肽及不良反应发生情况。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗后,两组视觉模拟评分法(VAS)、匹兹堡睡眠质量指数量表(PSQI)及皮肤病生命质量指数量表(DLQI)评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组P物质(SP)水平均低于治疗前,β-内啡肽(β-EP)水平均高于治疗前,且观察组SP水平低于对照组,β-EP水平高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论普瑞巴林联合利多卡因软膏治疗PHN效果显著,能调节患者SP、β-EP水平,改善者患疼痛、睡眠及生命质量,且未增加不良反应发生,临床应用安全可靠。Objective To investigate the effects of pregabalin combined with lidocaine on pain,plasma neuropeptide level and sleep quality patients with postherpetic neuralgia(PHN).Methods 88 patients with PHN who were treated in Daxing District Hospital of Integrated Chinese Western Medicine in Beijing from May 2020 to April 2022 were selected as the research subjects,and they were divided into the observation group and the control group according to random number table method,with 44 cases in each group.The control group was treated with lidocaine ointment,and the observation group was treated with pregabalin on the basis of the control group.The clinical efficacy,pain degree,sleep quality,quality of life,plasma neuropeptide and adverse reactions were compared between the two groups.Results The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05);after treatment,visual analogue scale(VAS),Pitts-burgh sleep quality index(PSQI)and dermatological life quality index(DLQI)scores of the two groups were lower than before treatment,and obser-vation group was lower than control group,the differences were statistically significant(P<0.05);after treatment,substance P(SP)level of the two groups was lower than before treatment,β-endorphin(β-EP)level was higher than before treatment,and SP in the observation group was lower than the control group,β-EP was higher than the control group,the differences were statistically significant(P<0.05).There was no significant difference in adverse reaction rate between the two groups.Conclusion The effect of pregabalin combined with lidocaine ointment in the treatment of PHN is significant,it can regulate the levels of SP andβ-EP in patients,improve pain,sleep and quality of life,and there was no increase the incidence of ad-verse reactions,the clinical application is safe and reliable.

关 键 词：带状疱疹后遗神经痛 普瑞巴林 利多卡因 疼痛 血浆神经肽 睡眠质量 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]