孟鲁司特钠联合氢溴酸右美沙芬治疗感染后咳嗽的疗效分析  

Analysis of the efficacy of montelukast sodium combined with dextromethorphan hydrobromide in the treatment of postinfectious cough

作　　者：黄静 杨侠 HUANG Jing;YANG Xia(Yicheng District People's Hospital,Zaozhuang 277300,China)

机构地区：[1]枣庄市峄城区人民医院,277300

出　　处：《中国实用医药》2024年第13期39-42,共4页China Practical Medicine

摘　　要：目的 对感染后咳嗽患者使用孟鲁司特钠联合氢溴酸右美沙芬进行治疗的效果进行分析。方法 选取64例感染后咳嗽患者,采取随机抽样法分为常规组与研究组,每组32例。常规组患者使用氢溴酸右美沙芬治疗,研究组患者使用孟鲁司特钠联合氢溴酸右美沙芬治疗。比较两组患者的治疗效果、不良反应发生率、咳嗽症状改善情况、血清炎性因子水平。结果 研究组和常规组的总有效率依次是96.88%、75.00%,差异性存在统计学意义(χ^(2)=6.335, P=0.012<0.05)。研究组治疗后7 d的咳嗽评分为(1.31±0.65)分,治疗后14 d的咳嗽评分为(0.98±0.40)分,均低于常规组的(1.88±0.97)、(1.39±0.73)分,差异性存在统计学意义(t=2.761、2.786, P=0.008、0.007<0.05)。研究组超敏C反应蛋白水平在治疗后7、14 d的水平分别为(15.08±2.17)、(6.38±1.07)mg/L,降钙素原水平在治疗后7、14 d的水平分别为(0.38±0.04)、(0.04±0.02)ng/ml,均低于常规组的(22.18±2.98)、(11.56±1.80)mg/L和(0.78±0.18)、(0.68±0.07)ng/ml,差异性存在统计学意义(t=10.895、13.993、12.271、49.730, P=0.000、0.000、0.000、0.000<0.05)。研究组不良反应发生率为9.38%,常规组不良反应发生率为6.25%,两组没有明显差异性(χ^(2)=0.216, P=0.641>0.05)。结论 为感染后咳嗽患者实施孟鲁司特钠+氢溴酸右美沙芬联合治疗疗效显著,临床应用价值较高。Objective To analyze the effect of montelukast sodium combined with dextromethorphan hydrobromide in the treatment of postinfectious cough.Methods A total of 64 patients with postinfectious cough were selected as the study subjects.The patients were randomly divided into a conventional group and a study group,each consisting of 32 cases.The conventional group was treated with dextromethorphan hydrobromide,while the study group was treated with montelukast sodium combined with dextromethorphan hydrobromide.The treatment effects,incidence of adverse reactions,improvement of cough symptoms,and serum levels of inflammatory factors of the two groups were compared.Results The total effective rate of the study group and the conventional group were 96.88%and 75.00%,respectively,and the differences were statistically significant(χ^(2)=6.335,P=0.012<0.05).The cough score of the study group was(1.31±0.65)points at 7 d after treatment,and(0.98±0.40)points at 14 d after treatment,both of which were lower than(1.88±0.97)and(1.39±0.73)points of the conventional group,and the differences were statistically significant(t=2.761,2.786,2.786;P=0.008,0.007<0.05).The levels of hypersensitive C-reactive protein in the study group were(15.08±2.17)and(6.38±1.07)mg/L,and the levels of procalcitonin in the study group were(0.38±0.04)and(0.04±0.02)ng/ml at 7 and 14 d after treatment,which were lower than(22.18±2.98),(11.56±1.80)mg/L and(0.78±0.18),(0.68±0.07)ng/ml in the conventional group,and the differences were statistically significant(t=10.895,13.993,12.271,and 49.730;P=0.000,0.000,0.000,and 0.000<0.05).The incidence of adverse reactions was 9.38%in the study group and 6.25%in the conventional group,and there was no significant difference between the two groups(χ^(2)=0.216,P=0.641>0.05).Conclusion The combined treatment of montelukast sodium and dextromethorphan hydrobromide for patients with postinfectious cough is effective and has high clinical application value.

关 键 词：孟鲁司特钠 氢溴酸右美沙芬 感染后咳嗽 疗效 

分 类 号：R56[医药卫生—呼吸系统]