2型糖尿病患者中性粒细胞和淋巴细胞比值与血糖水平、并发症的相关性研究  

Study on correlation of the neutrophil/lymphocyte ratio with blood glucose level and complications in patients with type 2 diabetes mellitus

作　　者：马丽状 王丽静 孙维燕 张筱玲 MA Li-zhuang;WANG Li-jing;SUN Wei-yan(Department of Endocrinology,Shidao People's Hospital,Rongcheng 264308,China)

机构地区：[1]荣成市石岛人民医院内分泌科,264308

出　　处：《中国实用医药》2024年第13期75-78,共4页China Practical Medicine

摘　　要：目的 研究2型糖尿病(T2DM)患者中性粒细胞和淋巴细胞比值(NLR)与血糖水平、并发症的相关性。方法 选择125例T2DM患者为研究对象,其中50例单纯T2DM纳入T2DM组, 75例T2DM伴并发症(包括冠心病、糖尿病肾病、视网膜病变等)纳入T2DMC组;30例健康体检者纳入对照组。(1)比较T2DM组、TD2MC组、对照组的基线资料[性别、年龄、体质量指数(BMI)、病程、白细胞计数(WBC)、收缩压(SBP)、舒张压(DBP)、总胆固醇(TC)、甘油三酯(TG)、超敏C反应蛋白(hs-CRP)、中性粒细胞计数、淋巴细胞计数]、血糖指标[空腹血糖(FPG)、糖化血红蛋白(HbA1c)]、NLR;(2)依据NLR将125例T2DM患者分为低NLR组(NLR≤2.35, 45例)、高NLR组(NLR>2.35, 80例),对比两组在入院时及治疗3个月后血糖水平、并发症发生率;(3)分析T2DM患者NLR与血糖水平、并发症的相关性。结果 三组WBC、TC、TG、FPG、HbA1c、hs-CRP、中性粒细胞计数、淋巴细胞计数及NLR比较有统计学意义(P<0.05);T2DM组、T2DMC组WBC、TC、TG、FPG、HbA1c、hs-CRP、中性粒细胞计数及NLR均高于对照组,淋巴细胞计数低于对照组;T2DMC组病程、WBC、TC、TG、FPG、HbA1c、hs-CRP、中性粒细胞计数及NLR均高于T2DM组,淋巴细胞计数低于T2DM组,有统计学意义(P<0.05)。125例T2DM患者中,入院时NLR≤2.35有45例, NLR>2.35有80例。治疗后,两组FPG、HbA1c均较本组入院时下降(P<0.05);高NLR组入院时与治疗3个月后FPG(9.70±0.98)、(7.48±0.79)mmol/L和HbA1c(8.33±0.85)、(7.46±0.74)%均高于低NLR组的(9.25±0.96)、(7.15±0.74)mmol/L和(8.00±0.84)、(7.13±0.75)%,入院时hs-CRP(2.98±0.34)mg/L、Gensini血管粥样硬化评分(60.13±6.45)分及并发症发生率67.50%也明显高于低NLR组的(2.46±0.25)mg/L、(43.12±4.39)分、46.67%(P<0.05)。相关分析显示:T2DM患者NLR与入院时FPG、HbA1c呈正相关,与治疗3个月后FPG、HbA1c、并发症发生率也呈正相关(P<0.05)。结论 T2DM患者NLR与其血糖水平、并�Objective To study the correlation of the neutrophil/lymphocyte ratio(NLR)with blood glucose level and complications in patients with type 2 diabetes mellitus(T2DM).Methods A total of 125 T2DM patients were studied,of which 50 T2DM patients were included in the T2DM group,75 cases of T2DM patients with complications(including coronary heart disease,diabetes nephropathy,retinopathy,etc.)were included in the T2DMC group;30 healthy subjects were included in the control group.(i)the baseline data[gender,age,body mass index(BMI),disease course,white blood cell count(WBC),systolic blood pressure(SBP),diastolic blood pressure(DBP),total cholesterol(TC),triglycerides(TG),hypersensitive C-reactive protein(hs CRP),neutrophil count,lymphocyte count],blood glucose indicators[fasting plasma glucose(FPG),glycated hemoglobin(HbA1c)]and NLR of T2DM group,TD2MC group and control group were compared.(ii)according to NLR,the 125 T2DM patients were divided into low NLR group(NLR≤2.35,45 cases)and high NLR group(NLR>2.35,80 cases).The blood glucose level and complication rate of the two groups were compared at admission,3 months after treatment.(iii)the correlation of NLR with blood glucose level and complications in T2DM patients was analyzed.Results There were significant differences in WBC,TC,TG,FPG,HbA1c,hs-CRP,neutrophil count,lymphocyte count and NLR among the three groups(P<0.05).WBC,TC,TG,FPG,HbA1c,hs-CRP,neutrophil count and NLR in T2DM group and T2DMC group were higher than those in the control group,while the lymphocyte count was lower than that in the control group;the disease course,WBC,TC,TG,FPG,HbA1c,hs-CRP,neutrophil count and NLR in T2DMC group were higher than those in T2DM group,and the lymphocyte count was lower than that in T2DM group;there was statistical significance(P<0.05).Among 125 T2DM patients,there were 45 cases with NLR≤2.35 and 80 cases with NLR>2.35 at admission.After treatment,FPG and HbA1c decreased in both groups compared with those at admission(P<0.05).In high NLR group,FPG were(9.70±0.98)and(

关 键 词：2型糖尿病 中性粒细胞和淋巴细胞比值 血糖 并发症 相关性 

分 类 号：R587.1[医药卫生—内分泌]