临床药师参与头孢哌酮舒巴坦致酒精性肝硬化患者癫痫持续状态的药物治疗实践  

Practice of clinical pharmacist participating in the drug treatment for status epilepticus in alcoholic liver cirrhosis patients induced by cefoperazone sulbactam

作　　者：王钊 马丽娟[2] 王梓凝[4] 姚文暾[3] Wang Zhao;Ma Lijuan;Wang Zining;Yao Wentun(Pharmacy Department,Peking University First Hospital Ningxia Women and Children's Hospital,Yinchuan 750001,China;Pharmacy Department,General Hospital of Ningxia Medical University,Yinchuan 750001,China;Gastroenterology,General Hospital of Ningxia Medical University,Yinchuan 750001,China;Department of Pharmacy,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学第一医院宁夏妇女儿童医院药剂科,宁夏银川750001 [2]宁夏医科大学总医院药剂科,宁夏银川750001 [3]宁夏医科大学总医院消化内科,宁夏银川750001 [4]北京大学第一医院药学部,北京100034

出　　处：《实用药物与临床》2024年第7期536-540,共5页Practical Pharmacy and Clinical Remedies

基　　金：宁夏回族自治区重点研发计划项目(2022BEG03129)。

摘　　要：1例酒精性肝硬化失代偿期患者使用头孢哌酮舒巴坦12 d后出现癫痫持续状态,临床药师对患者用药进行分析、评价,并查阅相关文献,考虑患者癫痫持续状态与头孢哌酮舒巴坦相关,建议停用,医生接受建议。患者停药后未再出现癫痫持续状态。临床药师持续监护患者病情变化,在其出现口腔颌面部间隙感染后,建议改用氨苄西林抗感染治疗,医生接收建议,患者经治疗后,颌面间隙感染得到控制,好转出院。本案例中临床药师参与该患者药物治疗过程,在减少药品不良反应、个体化治疗方案调整、特殊人群用药方案调整等方面起到关键作用,促进了患者临床安全合理用药。A patient with alcoholic liver cirrhosis in decompensated stage experienced status epilepticus after 12 days of cefoperazone sulbactam administration.Clinical pharmacists analyzed and evaluated the medication,and consulted relevant literatures,concluding that status epilepticus was associated with cefoperazone sulbactam.They recommended discontinuation of the medication,which the physician accepted.The patient did not experience status epilepticus after discontinuing the drug.The pharmacists continuously monitored the patient's condition,and upon observing an oral and maxillofacial space infection,advised switching to ampicillin for infection treatment.The physician agreed,and the patient's maxillofacial infection was controlled,leading to a favorable discharge.In this case,the clinical pharmacists have played a pivotal role in the patient's drug therapy by minimizing adverse drug reactions,tailoring treatment plans,and managing medications for special populations,ultimately facilitating safe and rational drug use in the clinical treatment.

关 键 词：头孢哌酮舒巴坦 酒精性肝硬化 癫痫持续状态 临床药师 药学监护 

分 类 号：R969[医药卫生—药理学]