NOD样受体蛋白3在心肌纤维化中的相关研究  

Correlation study on NOD-like receptor protein 3 in myocardial fibrosis

作　　者：郭梅凤 陈还珍[1] GUO Meifeng;CHEN Huanzhen(Department of Cardiovascular Medicine,The First Clinical Hospital of Shanxi Medical University,Taiyuan,Shanxi 030000,China)

机构地区：[1]山西医科大学第一临床医院心血管内科,山西太原030000

出　　处：《安徽医药》2024年第8期1503-1507,共5页Anhui Medical and Pharmaceutical Journal

摘　　要：心肌纤维化(MF)是导致心功能不全的主要原因,越来越多的证据表明无菌性炎症在导致心肌纤维化中起着非常重要的作用,NOD样受体(NLR)家族成员是控制炎症反应的核心角色,NOD样受体蛋白3(NLRP3)炎性体的NOD样受体家族吡喃结构域是最具特征的炎性体,现就NLRP3在多种疾病所致心肌纤维化中的作用及相关预防进行综述。Myocardial fibrosis(MF)is a major cause of cardiac insufficiency,a growing body of evidence suggests that aseptic inflammation in myocardial fibrosis plays a very important role,NOD like receptor(NLR)family members is to control the central role of inflammation,containing NLRP3 inflammasome NOD like receptor family pyran structure domain is the most characteristic of inflammasome.This article reviews the role and related prevention of NLRP3 in myocardial fibrosis caused by various diseases.

关 键 词：NOD样受体蛋白3(NLRP3) 心肌纤维化 炎症 

分 类 号：R542.23[医药卫生—心血管疾病]