捐赠母乳口腔免疫疗法对极低出生体重早产儿喂养耐受的影响  

Effect of oral immunotherapy with donor human milk on feeding tolerance in very low birth weight premature infants

作　　者：张肖肖 秦杨 高旭 于静静 边桂然 崔文焕 李娟 李桂芳 Zhang Xiaoxiao;Qin Yang;Gao Xu;Yu Jingjing;Bian Guiran;Cui Wenhuan;Li Juan;Li Guifang(Department of Neonatotogy,Cangzhou People's Hospital,Cangzhou 061000,China)

机构地区：[1]沧州市人民医院新生儿科,沧州061000

出　　处：《中华临床营养杂志》2024年第3期156-159,共4页Chinese Journal of Clinical Nutrition

摘　　要：目的观察捐赠母乳口腔免疫疗法对极低出生体重早产儿喂养耐受的影响。方法选择2022年8月至2024年2月沧州市人民医院新生儿科重症监护室收治的极低出生体重早产儿94例,根据随机数字表法分为两组,对照组47例,采用0.9%氯化钠口腔滴注,试验组47例,采用捐赠母乳口腔滴注,收集两组性别、分娩方式、是否双胎及小于胎龄儿、出生体重、胎龄及肠内喂养乳品等一般情况,统计比较各组达全肠道喂养时间、住院时间及早产儿喂养不耐受发生情况。结果试验组达全肠道喂养时间及住院时间短于对照组,差异有统计学意义(P<0.05),试验组喂养不耐受发生率低于对照组,差异有统计学意义(P<0.05)。结论捐赠母乳口腔免疫疗法能够改善极低出生体重早产儿喂养耐受情况,缩短住院时间。Objective To investigate the effect of oral immunotherapy with donor human milk on feeding tolerance in premature infants with very low birth weight.Methods A total of 94 extremely low birth weight preterm infants admitted to the neonatal Intensive Care Unit of Cangzhou People's Hospital from August 2022 to February 2024 were selected,These infants were randomized at 1:1 into 2 groups(47 cases each)using random number method.The control group were given oral 0.9%sodium chloride(oral drip),while the experimental group were given donor human milk(oral drip).General information were collected,including gender,delivery method,twins or not,small for gestational age or not,birth weight,gestational age,intestinal feeding of dairy products,and so on.Total intestinal feeding time,length of hospital stay and feeding intolerance were compared between groups.Results The total intestinal feeding time and length of hospital stay were significantly shorter in the experimental group compared with the control group(P<0.05).The incidence of feeding intolerance in the experimental group was also lower than that in the control group(P<0.05).Conclusion Oral immunotherapy with donor human milk can improve the feeding tolerance in premature infants with very low birth weight and shorten the hospital stay.

关 键 词：极低出生体重早产儿 捐赠母乳 口腔免疫疗法 早产儿喂养不耐受 

分 类 号：R722.6[医药卫生—儿科]