短链脂肪酸及免疫调节与脓毒症关系的研究进展  

Research progress of short-chain fatty acids and the relationship between immune regulation and sepsis

作　　者：车立媛 于占彪[1] 邹涵志 CHE Liyuan;YU Zhanbiao;ZOU Hanzhi(Intensive Care Unit,the Affiliated Hospital of Hebei University,Baoding,Hebei 071000,China)

机构地区：[1]河北大学附属医院重症医学科,河北保定071000

出　　处：《中国临床研究》2024年第6期939-942,共4页Chinese Journal of Clinical Research

基　　金：河北省医学科学研究课题计划(20231498)。

摘　　要：短链脂肪酸是一类由特定肠道菌群产生的饱和脂肪酸,具有维持肠道稳态、参与免疫调节等多种功能。近年来短链脂肪酸与炎症性疾病的关系逐渐成为研究的热点,众多研究表明,短链脂肪酸与脓毒症的发生及发展具有一定关联,可通过调控机体免疫细胞进而影响脓毒症患者的病情进展及预后。本文将短链脂肪酸及免疫调节与脓毒症的关系作一综述,以期为脓毒症的防治提供参考。Short-chain fatty acids are saturated fatty acids produced by specific intestinal flora,which have various functions such as maintaining intestinal homeostasis and participating in immune regulation.In recent years,the relationship between short-chain fatty acids and inflammatory diseases has gradually become a hot topic of research.Numerous studies have shown that short-chain fatty acids are associated with the occurrence and development of sepsis,and can affect the progression and prognosis of sepsis patients by regulating the body's immune cells.This article reviews the relationship between short-chain fatty acids,immune regulation and sepsis,in order to provide reference for the prevention and treatment of sepsis.

关 键 词：短链脂肪酸 免疫调节 脓毒症 组蛋白去乙酰化酶 G蛋白偶联受体 芳香烃受体 肠道菌群 

分 类 号：R459[医药卫生—治疗学]