芪冬颐心口服液联合氢溴酸西酞普兰用于PCI术后并发焦虑状态患者的效果  

Effect of qidong yixin oral liquid combined with citalopram hydrobromide in patients with anxiety after PCI

作　　者：张景鑫 王霏 常晓烨 苏海燕 曹文娟 常生荣 ZHANG Jing-xin;WANG Fe;CHANG Xiao-ye(Department of Cardiology,Zhangjiakou First Hospital,Zhangjiakou Hebei 075000,China)

机构地区：[1]张家口市第一医院心内科,河北张家口075000 [2]衡水市第四人民医院检验科,河北衡水053000 [3]衡水市第四人民医院药剂科,河北衡水053000

出　　处：《临床和实验医学杂志》2024年第11期1149-1153,共5页Journal of Clinical and Experimental Medicine

基　　金：河北省医学科学研究重点课题计划项目(编号:20232064);张家口市2022年科技计划自筹经费项目(编号:2221060D)。

摘　　要：目的 观察芪冬颐心口服液联合氢溴酸西酞普兰用于经皮冠状动脉介入治疗(PCI)术后并发焦虑状态患者的效果。方法 回顾性选取2020年9月至2023年3月张家口市第一医院收治的首次发作急性心肌梗死后接受PCI术3个月后并发焦虑状态的40例患者作为研究对象。按照简单随机法将其分为对照组(n=20)和联合组(n=20)。两组均给予对症治疗,对照组给予氢溴酸西酞普兰治疗,联合组在对照组基础上联合芪冬颐心口服液治疗。评估并比较两组治疗前和治疗3个月后的汉密尔顿焦虑量表(HAMA)评分、匹兹堡睡眠质量指数量表(PSQI)评分、中医症状评分的差异,比较两组治疗前和治疗3个月后的心功能[左心室舒张末内径(LVEDD)、左心室收缩末内径(LVESD)、二尖瓣口舒张早期与晚期峰值血流速度比值(E/A)、左室射血分数(LVEF)]、B型脑钠肽(BNP)、炎症因子[高敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)]水平,统计两组主要心血管不良事件(MACE)发生率。结果 治疗3个月后,联合组的总有效率为95.00%,高于对照组(70.00%),差异有统计学意义(P<0.05)。治疗3个月后,两组HAMA评分、PSQI评分、中医症状评分均较治疗前明显下降,且联合组HAMA评分、PSQI评分、中医症状评分分别为(13.06±2.14)、(7.56±1.25)、(6.22±0.78)分,均低于对照组[(14.45±2.03)、(8.94±1.47)、(8.91±1.12)分],差异均有统计学意义(P<0.05)。治疗3个月后,两组LVEDD、LVESD均较治疗前明显下降,E/A、LVEF均较治疗前明显升高,且联合组的LVEDD、LVESD分别为(37.85±3.45)、(38.12±3.11) mm,均低于对照组[(41.35±3.67)、(40.79±3.76) mm],E/A、LVEF分别为1.45±0.31、(52.78±4.36)%,均高于对照组[1.24±0.28、(49.64±4.27)%],差异均有统计学意义(P<0.05)。治疗3个月后,两组BNP、hs-CRP、IL-6、TNF-α水平均较治疗前明显下降,且联合组BNP、hs-CRP、IL-6、TNF-α水平分别为(274.14±105.67)pObjective To observe the effect of qidong yixin oral liquid combined with citalopram hydrobromide in patients with anxiety after percutaneous coronary intervention(PCI).Methods Forty patients with anxiety 3 months after PCI after the first-time acute myocardial infarction,who admitted to Zhangjiakou First Hospital from September 2020 to March 2023 were retrospectively selected as the study subjects,and divide them into the control group(n=20)and the combination group(n=20)according to the simple random method.Both groups were given symptomatic treatment,the control group was given citalopram hydrobromide treatment,and the combined group was treated with qidong yixin oral liquid on the basis of the control group.The differences of Hamilton anxiety scale(HAMA)score,Pittsburgh sleep quality index(PSQI)score and Chinese medicine symptom score before treatment and after 3 months of treatment between the two groups were evaluated and compared.The levels of cardiac function[left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter(LVESD),the ratio of peak blood flow velocity(E/A)and left ventricular ejection fraction(LVEF)],B-type brain natriuretic peptide(BNP)and inflammatory indicators[high-sensitive C-reactive protein(hs-CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)]before treatment and after 3 months of treatment between the two groups were compared.And the incidence of major cardiovascular adverse events(MACE)between the two groups were analyzed.Results After 3 months of treatment,the total effective rate of the combination group was 95.00%,which was higher than that of the control group(70.00%),and the difference was statistically significant(P<0.05).After 3 months of treatment,the HAMA score,PSQI score,and Chinese medicine symptom score in two groups were significantly lower than those before treatment,and the HAMA score,PSQI score,and traditional Chinese medicine symptom score in the combination group were(13.06±2.14),(7.56±1.25),and(6.22±0.78)points,respectively,

关 键 词：焦虑 心肌梗死 芪冬颐心口服液 氢溴酸西酞普兰 焦虑状态 心功能 睡眠质量 炎症反应 

分 类 号：R542.22[医药卫生—心血管疾病]