声带息肉患者应用支撑喉镜等离子手术治疗后嗓音恢复、氧化应激及炎症因子水平观察  

Observation of voice recovery,oxidative stress,and inflammatory factors levels in patients with vocal cord polyps after plasma surgery with support laryngoscopy

作　　者：杨永侠 郭雷 陈雪 YANG Yong-xia;GUO Lei;CHEN Xue(Eastern Department of Otolaryngology,The First Affiliated Hospital of Anhui Medical University,Hefei Anhui 230022,China)

机构地区：[1]安徽医科大学第一附属医院东区耳鼻咽喉科,安徽合肥230022

出　　处：《临床和实验医学杂志》2024年第11期1218-1222,共5页Journal of Clinical and Experimental Medicine

基　　金：安徽省自然科学基金项目(编号:1808085QH280)。

摘　　要：目的 观察声带息肉患者应用支撑喉镜等离子手术治疗后嗓音恢复、氧化应激及炎症因子水平。方法 回顾性选取安徽医科大学第一附属医院2021年2月至2023年4月入院治疗的60例实施声带息肉切除术患者为研究对象,按照手术方式不同将患者分为观察组(n=33)及对照组(n=27)。观察组行支撑喉镜等离子手术进行治疗,对照组行支撑喉镜显微切除术进行治疗。比较两组患者术后1 d血清氧化应激指标[超氧化物歧化酶T(SOD T)、超氧化物歧化酶Cu-Zn(SOD Cu-Zn)、过氧化氢(H2O2)、晚期蛋白氧化产物(AOPP)、总抗氧化能力(T-AOC)]水平,术前及术后1 d炎症因子[白细胞介素(IL)-6、IL-1β及肿瘤坏死因子-α(TNF-α)],术前、术后2周嗓音质量指标[嗓音基频微扰值百分数(Jitter%)、噪声能量、嗓音振幅微扰值百分数(shimme%)、谐噪比],术后1个月生活质量,并比较两组患者并发症发生情况。结果 观察组术后1 d的SOD T、SOD Cu-Zn、T-AOC水平分别为(52.74±5.84) IU/mL、(30.47±4.16) IU/mL、(13.17±1.86) U/mL,均显著高于对照组,H2O2、AOPP水平分别为(17.49±2.45) nmol/L、(41.36±4.82)μmol/L,均低于对照组,差异均有统计学意义(P<0.05)。术后1 d,两组IL-6、IL-1β、TNF-α水平较术前均降低,且观察组IL-6、IL-1β、TNF-α水平分别为(116.89±12.74)、(140.85±14.74)、(113.85±13.63) ng/L,均低于对照组,差异均有统计学意义(P<0.05)。术后2周,两组患者Jitter%、shimme%均较术前降低,噪声能量、谐噪比均较术前上升,且观察组患者的Jitter%、shimme%分别为(0.20±0.02)%、(1.58±0.34)%,均低于对照组,噪声能量、谐噪比分别为(16.54±2.51)、(26.78±2.47) dB,均高于对照组,差异均有统计学意义(P<0.05)。术后1个月,观察组患者躯体健康、心理健康、物质生活、社会功能评分分别为(21.34±3.25)、(22.47±4.38)、(15.69±3.65)、(17.60±3.75)分,均高于对照组,差异均有统计学意义(P<0.05)。观察组并�Objective To observe the voice recovery,oxidative stress and inflammation factors level in patients with vocal cord polyp.Methods Sixty patients who underwent vocal cord polypectomy at the First Affiliated Hospital of Anhui Medical University from February 2021 to April 2023 were retrospectively selected as the study subjects.Patients were divided into the observation group(n=33)and the control group(n=27)according to different surgical methods.The observation group underwent plasma surgery with a supporting laryngoscope,while the control group underwent microsurgery with a supporting laryngoscope.The levels of serum oxidative stress indicators[superoxide dismutase T(SOD T),superoxide dismutase Cu-Zn(SOD Cu-Zn),hydrogen peroxide(H 2O 2),advanced oxidation protein products(AOPP),total antioxidant capacity(T-AOC)]at 1 day after surgery,inflammatory factors[interleukin-6(IL-6),IL-1β,and tumor necrosis factor-α(TNF-α)]before surgery and 1 day after surgery,and voice quality indicators[the values for voice fundamental frequency perturbation percentage(Jitter%),noise energy,voice amplitude perturbation percentage(shimmer%),and harmonic to noise ratio]before surgery and at two weeks after surgery were compared between two groups of patients,the quality of life at the 1 month after surgery was compared between the two groups of patients.The incidence of complications between the two groups of patients was compared.Results The levels of SOD T,SOD Cu-Zn,and T-AOC in the observation group at 1 day after surgery were(52.74±5.84)IU/mL,(30.47±4.16)IU/mL,and(13.17±1.86)U/mL,respectively,which were significantly higher than those in the control group,the levels of H 2O 2 and AOPP were(17.49±2.45)nmol/L and(41.36±4.82)μmol/L,respectively,which were lower than those in the control group,the differences were statistically significant(P<0.05).At 1 day after surgery,the levels of IL-6,IL-1β,and TNF-αin two groups were lower than those before surgery,and the levels of IL-6,IL-1β,and TNF-αin the observation group were(116.

关 键 词：声带息肉 支撑喉镜等离子手术 支撑喉镜显微切除术 嗓音恢复 氧化应激 炎症因子 

分 类 号：R767.91[医药卫生—耳鼻咽喉科]