血清IgE、IgA、EOS及WBC计数水平的表达及与儿童慢性咳嗽发生的关系  

Expression of serum IgE,IgA,EOS,and WBC levels and their relationship with the occurrence of chronic cough in children

作　　者：郭艳霞 左艳芳 李洪娜 沈丹华 王荣 杨秀平 GUO Yan-xia;ZUO Yan-fang;LI Hong-na(Department of Pediatrics,Cangzhou People's Hospital,Cangzhou Hebei 061000,China)

机构地区：[1]沧州市人民医院儿科,河北沧州061000

出　　处：《临床和实验医学杂志》2024年第12期1320-1323,共4页Journal of Clinical and Experimental Medicine

基　　金：河北省医学科学研究课题计划(编号:20220302)。

摘　　要：目的观察血清免疫球蛋白(Ig)E、IgA、嗜酸性粒细胞(EOS)及白细胞(WBC)计数水平与儿童慢性咳嗽发生的关系。方法回顾性选择2022年2月至2023年7月沧州市人民医院收治的195例慢性咳嗽患儿作为慢性咳嗽组,另收集同期于本院诊治的195例急性支气管炎患儿作为急性支气管炎组。统计慢性咳嗽患儿病因;收集并比较两组患儿的一般资料,包括性别、年龄、体重指数、既往慢性咳嗽史、家族疾病、灰尘暴露、父母吸烟、中性粒细胞(NE)百分比、淋巴细胞计数、淋巴细胞百分比、单核细胞计数、IgE、IgA、EOS百分比、WBC计数;采取非条件Logistic逐步回归分析儿童慢性咳嗽发生的危险因素;通过受试者操作特征(ROC)曲线分析IgE、IgA、EOS评估儿童慢性咳嗽发生的价值。结果195例慢性咳嗽患儿中,病因占比最多的是呼吸道感染后咳嗽(PIC)为26.67%,其次是上气道咳嗽综合征(UACS)及咳嗽变异性哮喘(CVA),分别为20.51%、20.00%。两组性别、年龄、体重指数、灰尘暴露、NE百分比、淋巴细胞计数、淋巴细胞百分比、单核细胞计数、WBC计数组间比较,差异均无统计学意义(P>0.05);慢性咳嗽组既往慢性咳嗽史占比、家族疾病史占比、父母吸烟占比、IgE、IgA、EOS百分比均高于急性支气管炎组,差异均有统计学意义(P<0.05)。经多因素Logistic回归分析证实,既往慢性咳嗽史、家族疾病史、父母吸烟、IgE、IgA、EOS百分比是儿童慢性咳嗽发生的危险因素(P<0.05)。ROC曲线分析结果显示,IgE、IgA、EOS评估儿童慢性咳嗽发生的曲线下面积分别为0.959、0.690、0.922,且P<0.05。结论既往慢性咳嗽史、家族疾病史、父母吸烟、IgE、IgA、EOS百分比是儿童慢性咳嗽发生的危险因素,临床需对以上因素密切关注。Objective To observe the relationship between serum immunoglobulin(Ig)E,IgA,eosinophils(EOS),and white blood cell(WBC)count levels and the occurrence of chronic cough in children.Methods A total of 195 children with chronic cough admitted to Cangzhou People's Hospital from February 2022 to July 2023 were retrospectively selected as the chronic cough group,and the clinical data of 195 children with acute bronchitis treated in the same hospital during the same period were also collected as the acute bronchitis group.The causes of chronic cough were counted;the general data of two groups of children were collected and compared,including sex,age,body mass index,previous history of chronic cough,family disease,dust exposure,parental smoking,neutrophile granulocyte(NE)percentage,lymphocyte count,lymphocyte percentage,monocyte count,IgE,IgA,EOS percentage,and WBC count;the risk factors of chronic cough in children were analyzed by unconditioned Logistic stepwise regression;the value of IgE,IgA and EOS in evaluating the occurrence of chronic cough in children was analyzed by receiver operating characteristic(ROC)curve.Results Among 195 children with chronic cough,the most common cause was post respiratory infection cough(PIC),which accounted for 26.67%,followed by upper airway cough syndrome(UACS)and cough variant asthma(CVA),which accounted for 20.51%and 20.00%,respectively.There were no statistically significant differences in gender,age,body mass index,dust exposure,NE percentage,lymphocyte count,lymphocyte percentage,monocyte count and WBC between the two groups(P>0.05).The proportion of previous chronic cough history,the proportion of family disease history,the proportion of parents smoking,the levels of IgE,IgA and EOS percentage in the chronic cough group were higher than those in the acute bronchitis group,the differences were statistically significant(P<0.05).Multivariate Logistic regression analysis confirmed that previous history of chronic cough,family history of disease,parental smoking,IgE,IgA and EOS perce

关 键 词：咳嗽 儿童 免疫球蛋白E 免疫球蛋白A 嗜酸性粒细胞 危险因素 

分 类 号：R725.6[医药卫生—儿科]