丹参川芎嗪联合针刺疗法对急性颅脑损伤患者神经功能及炎症因子水平的影响  

Impacts of radix salviae miltiorrhizae and ligustrazine combined with acupuncture therapy on neurological function and inflammatory factor levels in patients with acute craniocerebral injury

作　　者：倪腾 郭文龙[1] NI Teng;GUO Wenlong(Department of Emergency,the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Hunan,Zhuzhou 412000,China)

机构地区：[1]湖南中医药高等专科学校附属第一医院急诊科,湖南株洲412000

出　　处：《中国医药科学》2024年第12期146-149,191,共5页China Medicine And Pharmacy

基　　金：湖南省株洲市创新型城市建设专项社会化出资项目。

摘　　要：目的观察丹参川芎嗪联合针刺疗法对急性颅脑损伤患者神经功能及炎症因子表达水平的影响。方法选取2022年9月至2023年9月在湖南中医药高等专科学校附属第一医院急诊科住院的急性颅脑损伤患者80例,按照随机数表法将其分为对照组和观察组,每组各40例。对照组予以西医常规治疗;观察组在对照组基础上予以丹参川芎嗪注射液5 ml,1次/d,静脉滴注,并配合针刺疗法,两组疗程均为7 d。观察两组患者治疗前后的肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、C反应蛋白(CRP)、日常生活能力(ADL)评分、神经功能评分(NIHSS)变化。结果80例患者在治疗观察过程中脱落5例,最终入组75例,对照组37例,观察组38例。治疗后,两组总有效率比较,差异无统计学意义(P>0.05)。治疗后,观察组NIHSS及ADL评分低于对照组,差异有统计学意义(P<0.05);观察组IL-6、IL-8、TNF-α及CRP表达水平低于对照组,差异有统计学意义(P<0.05)。结论丹参川芎嗪注射液联合针刺疗法能够有效降低急性颅脑损伤患者的炎症因子水平,减轻患者神经功能缺损,提高患者日常生活自理能力,临床疗效良好。Objective To observe the im pacts of radix s alviae miltiorrhizae and ligus trazine combined with acupuncture therapy on neurological function and inflammatory factor expression levels in patients with acute craniocerebral injury.Methods A total of 80 patients with acute craniocerebral injury hospitalized in the Department of Emergency of the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine from September 2022 to September 2023 were selected and divided into the control group(n=40)and the observation group(n=40)according to the random number table method.The control group was treated with conventional western medicine.While on the basis of the control group,the observation group was treated with 5 ml injection of radix salviae miltiorrhizae and ligustrazine intravenous drip once a day,and combined with acupuncture therapy.The course of treatment in both groups was 7 days.The changes of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8),C-reactive protein(CRP),ability of daily living(ADL)and neurological function score(National Institute of Health stroke scale,NIHSS)in the two groups of patients were observed before and after treatment.Results Of the 80 patients,5 cases fell off during the treatment and observation,and finally 75 cases entered the group,which was divided into the control group(n=37)and the observation group(n=38).After treatment,there was no statistically significant difference in the overall response rate between the two groups(P>0.05).After treatment,the scores of NIHSS and ADL in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).The expression levels of IL-6,IL-8,TNF-αand CRP in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).Conclusion Inj ection o f ra dix sa lviae mi ltiorrhizae a nd l igustrazine c ombined w ith a cupuncture therapy can effectively reduce the levels of inflammatory factors in patients with a

关 键 词：急性颅脑损伤 针剂疗法 丹参川芎嗪注射液 神经功能 炎症因子水平 

分 类 号：R651.15[医药卫生—外科学]