代谢健康型肥胖与新型简化胰岛素抵抗评价指标的关系探讨  

Investigation on the correlation between metabolically healthy obesity and new simplified evaluation index of insulin resistance

作　　者：周鑫[1] 孙若琳 张波[1] 胡益 王为强[1] ZHOU Xin;SUN Ruolin;ZHANG Bo;HU Yi;WANG Weiqiang(Department of General Medicine,Suzhou Hospital of Anhui Medical University,Suzhou Municipal Hospital of Anhui Province,Anhui,Suzhou 234000,China)

机构地区：[1]安徽医科大学附属宿州医院(安徽省宿州市立医院)全科医学科,安徽宿州234000

出　　处：《中国医药科学》2024年第12期167-170,共4页China Medicine And Pharmacy

基　　金：安徽省科技创新战略与软科学研究专项(202106f01050042)。

摘　　要：目的探讨代谢健康型肥胖(MHO)与新型简化胰岛素抵抗评价指标的关系。方法选取2020年9月至2021年3月在安徽省宿州市某社区进行健康体检的人群中选择肥胖人群,基于代谢异常情况分为代谢异常型肥胖组(MUO)313例和MHO组118例,同期选取体重及代谢正常人群设为健康对照组(HC)87名。三组均进行一般信息问卷调查以及新型简化胰岛素抵抗评价指标检查,采用单因素及logistic回归模型分析新型胰岛素抵抗评价指标与MHO患者的关系。结果logistic回归分析结果显示,MHO组的TyG-体重指数(TyG-BMI)、TyG-腰围指数(TyG-WC)、胰岛素敏感性评分(e-IS),组间差异有统计学意义(P均<0.05)。结论MHO患者与TyG-BMI、TyG-WC、e-IS改变显著相关,发生胰岛素抵抗风险明显增加,为早期干预人群提供理论依据。Objective To investigate the correlation between metabolically healthy obesity(MHO)and new simplified evaluation index of insulin resistance.Methods Obese population undergoing health examinations in a community in Suzhou,Anhui Province from September 2020 to March 2021 were selected,and they were divided into the metabolically unhealthy obesity(MUO)group(n=313)and the MHO group(n=118)based on metabolic abnormalities,and population with normal body weight and metabolism during the same period were selected and divided into the healthy control(HC)group(n=87).All 3 groups were investigated by general information questionnaire and the new simplified evaluation index examination of insulin resistance.The correlation between the new evaluation indices of insulin resistance and MHO patients was analyzed by univariate and logistic regression models.Results Logistic regression analysis showed that there were statistically significant differences in the TyG-BMI index(TyG-BMI),TyG waist circumference index(TyG-WC)and insulin sensitivity score(e-IS)between the population in the MHO group and other groups(all P<0.05).Conclusion MHO patients are significantly correlated with the changes of TyG-BMI,TyGWC and e-IS,and the risk of developing insulin resistance is significantly increased,providing a theoretical basis for early intervention in this population.

关 键 词：代谢健康型肥胖 代谢异常型肥胖 胰岛素抵抗 肥胖表型 

分 类 号：R587.1[医药卫生—内分泌]