硫酸镁联合拉贝洛尔治疗妊娠期高血压疾病的应用及临床预后观察  

The application and clinical prognosis observation of magnesium sulfate combined with rabelol in the treatment of gestational hypertension

作　　者：王晓燕 Wang Xiaoyan(Department of Obstetrics,People's Hospital of Pingle County,Guilin 542400,China)

机构地区：[1]广西平乐县人民医院产科,广西桂林542400

出　　处：《实用妇科内分泌电子杂志》2024年第15期80-82,共3页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的观察硫酸镁联合拉贝洛尔治疗妊娠期高血压疾病的应用及临床预后效果。方法选取本院收治的93例妊娠期高血压疾病患者为研究对象,按照随机数字表法分为两组。对照组(46例)采用硫酸镁治疗,观察组(47例)在对照组的基础上加用拉贝洛尔治疗,比较两组各项指标。结果治疗后,两组患者的收缩压、舒张压均降低,且观察组低于对照组(P<0.05)。治疗后,两组患者的Lp-PLA2均降低,且观察组低于对照组;两组HLA-G、GATA-3均上升,且观察组高于对照组(P<0.05)。两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论妊娠期高血压疾病患者联用硫酸镁和拉贝洛尔,可有效控制血压指标,降低Lp-PLA2,提升HLA-G、GATA-3,有助于避免产妇和胎儿不良结局发生,且用药期间不增加不良反应发生风险,安全性有保障。Objective To observe the application and clinical prognosis of magnesium sulfate combined with rabelol in the treatment of gestational hypertension.Methods 93 patients with gestational hypertension admitted to our hospital were selected as the research subjects and divided into two groups using a random number table method.The control group(46 cases)was treated with magnesium sulfate,while the observation group(47 cases)was treated with Labelol in addition to the control group.The various indicators of the two groups were compared.Results After treatment,the systolic and diastolic blood pressure of both groups of patients decreased,and the observation group was lower than the control group(P<0.05).After treatment,the Lp PLA2 levels of both groups of patients decreased,and the observation group was lower than the control group;Both HLA-G and GATA-3 levels increased in both groups,and the observation group was higher than the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups of patients(P>0.05).Conclusion The combination of magnesium sulfate and rabelol in patients with gestational hypertension can effectively control blood pressure indicators,reduce Lp-PLA2,improve HLA-G and GATA-3,help avoid adverse outcomes for both mother and fetus,and do not increase the risk of adverse reactions during medication,ensuring safety.

关 键 词：硫酸镁 拉贝洛尔 妊娠期高血压疾病 

分 类 号：R714.246[医药卫生—妇产科学]