系统性自身炎症性疾病的肾脏损伤  

Kidney injury in systemic autoinflammatory diseases

作　　者：王大海 常红[1] WANG Da-hai;CHANG Hong(Department of Nephrology,Rheumatology,and Immunology,the Affiliated Hospital of Qingdao University,Qingdao 266003,China)

机构地区：[1]青岛大学附属医院儿童肾脏风湿免疫科,山东青岛266003

出　　处：《中国实用儿科杂志》2024年第6期456-462,共7页Chinese Journal of Practical Pediatrics

摘　　要：肾脏是系统性自身炎症性疾病较易累及的靶器官之一,临床可表现为蛋白尿、肾病综合征、肾功能不全,如延误诊断和治疗可导致肾衰竭甚至死亡。发病机制包括炎症持续存在或反复发生导致的肾淀粉样变性和基于炎症小体激活的肾血管炎,此外还有更罕见的其他各种类型的肾小球肾炎。提高对自身炎症性疾病的认识和早期识别,出现肾脏损伤时及时获取病理,对疾病的早期恢复和改善预后至关重要。The kidney is a major target organ of systemic autoinflammatory diseases.The clinical manifestations vary from proteinuria,nephrotic syndrome,and renal insufficiency which may end up requiring renal failure or death.The pathogenetic mechanisms are likewise quite diverse,ranging fromamyloidosisca used by persistentor recurrent inflammation to inflammasome activation-mediated vasculitis/vasculopathy and several other uncommon types of glomerulonephritis.It is critical to increase the understanding and early identification of autoinflammatory diseases,as well as acquire pathology in time when renal injury occurs,to enhance disease recovery and prognosis.

关 键 词：系统性自身炎症性疾病 肾脏损伤 肾淀粉样变性病 AA淀粉样变性 

分 类 号：R72[医药卫生—儿科]