维生素D对脑内多巴胺神经系统的调节作用  

Vitamin D Plays a Crucial Role in Regulating Dopamine Nervous System in Brain

作　　者：王华林 赵旭东 刘冉 李科 侯莉娟[1] WANG Hua-Lin;ZHAO Xu-Dong;LIU Ran;LI Ke;HOU Li-Juan(School of Physical Education and Sports,Beijing Normal University,Beijing 100875,China;College of Chemistry,Beijing Normal University,Beijing 100875,China)

机构地区：[1]北京师范大学体育与运动学院,北京100875 [2]北京师范大学化学学院,北京100875

出　　处：《生物化学与生物物理进展》2024年第7期1530-1539,共10页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(31971095)资助项目。

摘　　要：维生素D(vitamin D,VD)是一种神经活性类固醇,可以调节神经递质合成、维持细胞内钙稳态,在脑内发挥调节神经元兴奋性、保护神经细胞等作用。新近研究表明,VD与多巴胺(dopamine,DA)能神经元介导的动机、奖赏、学习和运动等行为有关,VD不仅可促进DA合成,调节脑内DA水平,还从多种角度对DA能神经元发挥神经保护作用。本文将介绍VD的合成、代谢及作用途径,探讨VD对DA能神经元调控机制,为动机、奖赏等行为的研究提供理论参考。Vitamin D is a unique fat-soluble vitamin that plays an indispensable role in human health.It exists in various forms,the most significant being vitamin D_(2)(derived from plant sources)and vitamin D_(3)(synthesized naturally in human skin upon exposure to sunlight).Vitamin D’s primary function is to facilitate the absorption of calcium and phosphorus,which are crucial for maintaining healthy bones.Beyond its role in bone health,vitamin D significantly influences the immune system,muscle function,cardiovascular health,and the regulation of brain functions.A deficiency in vitamin D can lead to various chronic diseases such as rickets,osteoporosis,decreased immunity,increased risk of mental disorders,and cancers.The synthesis of vitamin D in the human body,both peripherally and centrally,relies on sunlight exposure,dietary sources,and various supplements.As a neuroactive steroid,vitamin D impacts both the physiological and pathological processes of the nervous system and plays a key role in brain health.It profoundly affects the brain by regulating neurotransmitter synthesis and maintaining intracellular calcium balance.As an essential chemical molecule,vitamin D participates in complex signal transduction pathways,impacting neurotransmitter functions and synaptic plasticity.Vitamin D’s role in regulating dopamine(DA)—a neurotransmitter critical for motivation,reward perception,and other higher cognitive functions—is particularly noteworthy.Recent studies have revealed that vitamin D not only promotes the synthesis of DA but also plays a role in regulating DA levels within the brain.It exerts neuroprotective effects on DA neurons through anti-inflammatory,antioxidant actions,and neurotrophic support,thereby creating an optimal environment for DA neurons,influencing neuronal structure,and affecting the movement of calcium ions within nerve cells,positively impacting the overall health and functionality of the DA system.Furthermore,vitamin D can regulate the synthesis and release of DA,thus affecting the sign

关 键 词：维生素D 多巴胺神经系统 调控功能 突触可塑性 

分 类 号：Q42[生物学—神经生物学] Q565[生物学—生理学]