不同途径给药恩诺沙星对豚鼠体质量和血液生理生化指标的影响  

Effects of Different Routes of Enrofloxacin Administration on Body Weight and Blood Physiological and Biochemical Indexes of Guinea Pigs

作　　者：董浩 刘志国 刘金生 武卫国 王学文 张乐颖 董青花 朱婉月 马丽颖[1] 左琴[1] DONG Hao;LIU Zhiguo;LIU Jinsheng;WU Weiguo;WANG Xuewen;ZHANG Leying;DONG Qinghua;ZHU Wanyue;MA Liying;ZUO Qin(National Institutes for Food and Drug Control,National Rodent Laboratory Animal Resources Center,Beijing 102629,China)

机构地区：[1]中国食品药品检定研究院国家啮齿类实验动物资源库,北京102629

出　　处：《实验动物科学》2024年第3期40-45,共6页Laboratory Animal Science

摘　　要：目的测定不同途径进行恩诺沙星给药,对豚鼠体质量变化和血液生理生化指标的影响。方法分别测定不同途径进行恩诺沙星给药对豚鼠体质量、血液生理指标和血液生化指标的影响,利用统计学方法分析组间差异。结果高剂量恩诺沙星饮水给药会显著影响豚鼠的饮水量,高剂量恩诺沙星和低剂量恩诺沙星饮水给药都会显著影响豚鼠的体质量增长。在血液生理指标方面,不同给药处理组中的白细胞计数WBC、单核细胞绝对值MON、中性粒细胞绝对值GRAN、平均红细胞血红蛋白浓度MCHC、红细胞分布宽度变异系数RDW-CV、血小板分布宽度PDW等6项指标与对照组相比具有统计学意义(P<0.05)。在血液生化指标方面,与对照组相比,不同给药处理组中的钙Ca、丙氨酸氨基转移酶ALT、碱性磷酸酶ALP、γ-谷氨酰转肽酶γ-GT、三酰甘油TG等5项指标具有统计学意义。结论不同途径恩诺沙星给药对豚鼠多项生物学指标影响的测定,为豚鼠的科学用药提供了基础数据。Objective To study the effects of different routes of enrofloxacin administration on body weight and blood physiological and biochemical indexes of guinea pigs,this study was performed.Method The effects of different routes of enrofloxacin administration on body weight,blood physiological and biochemical indexes of guinea pigs were determined respectively.Statistical method were used for data analysis.Result High dose of enrofloxacin administered by drinking water significantly affected the water consumption of guinea pigs.Both high dose of enrofloxacin and low dose of enrofloxacin significantly affected the weight gain of guinea pigs.Compared to the control group,several significantly different blood physiological indexes were determined in the administration treatment groups including WBC,MON,GRAN,MCHC,RDW-CV,PDW.In terms of blood biochemical indexes,five parameters(Ca,ALT,ALP,γ-GT,and TG)were also affected after administration,compared to the control group.Conclusion The determination of the effects of different routes of enrofloxacin administration on several biological indexes of guinea pigs would provide basic data for scientific medication in guinea pigs.

关 键 词：恩诺沙星 豚鼠 血液生理指标 血液生化指标 

分 类 号：S855.1[农业科学—临床兽医学] Q95-3[农业科学—兽医学]