前列舒通胶囊联合盐酸坦索罗辛治疗慢性前列腺炎的Meta分析  

Meta-analysis of Qianlie Shutong Capsule Combined with Tamsulosin Hydrochloridein the Treatment of Chronic Prostatitis

作　　者：丁克凡 范春美 马斯棋 张春和 陈淑慧 赵梓钦 文鑫邦 杨毅坚 DING Ke-fan;FAN Chun-mei;MA Si-qi;ZHANG Chun-he;CHEN Shu-hui;ZHAO Zi-qin;WEN Xin-bang;YANG Yi-jian(Yunnan University of Traditional Chinese Medicine,Kunming 650500,China;The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine,Kunming 650021,China)

机构地区：[1]云南中医药大学,云南昆明650500 [2]云南中医药大学第一附属医院,云南昆明650021

出　　处：《云南中医中药杂志》2024年第6期28-32,共5页Yunnan Journal of Traditional Chinese Medicine and Materia Medica

基　　金：国家自然科学基金地区科学基金项目(81860853)。

摘　　要：目的基于Meta分析系统评价前列舒通胶囊联合盐酸坦索罗辛治疗慢性前列腺炎的有效性及安全性。方法计算机检索中国知网、PubMed、万方等6个中、英文数据库,收集前列舒通胶囊联合盐酸坦索罗辛治疗CP的临床随机对照试验(RCT)。文献检索年限为建库初始至2023年2月,依据疾病的纳入和排除标准提取数据,采用RevMan5.4软件进行Meta分析。结果共纳入9项研究,共894例患者。Meta分析结果显示:前列舒通胶囊联合盐酸坦索罗辛治疗CP能显著提高临床有效性[OR=4.50,95%CI(2.35,7.41),P<0.00001],降低前列腺炎症状指数(NIH-CPSI评分)[MD=-6.02,95%CI(-7.68,-4.36),P<0.00001]、清除前列腺液白细胞[MD=-7,61,95%CI(-8.47,-6.74),P<0.00001]、改善最大尿流率[MD=3.31,95%CI(0.93,5.69),P<0.00001]。结论前列舒通胶囊联合盐酸坦索罗辛治疗CP能明显提高临床有效性,降低NIH-CPSI评分,清除前列腺液白细胞,改善最大尿流率,减少不良反应。Objective:To systematically evaluate the efficacy and safety of Qianlie Shutong Capsule combined with tamsulosin hydrochloride in the treatment of chronic prostatitis(CP)based on meta-analysis.Methods:The randomized controlled trials(RCT)of Qianlie Shutong Capsule combined with tamsulosin hydrochloride in the treatment of CP was collected by computer searching six Chinese and English databases including CNGI.cn,PubMed and Wanfang.The literature search period was from the beginning of the database to February 2023.Data were extracted according to the inclusion and exclusion criteria of diseases,and meta-analysis was performed using RevMan5.4 software.Results:Nine studies with a total of 894 patients were included.The results of meta-analysis showed Qianlie Shutong Capsule combined with tamsulosin hydrochloride in the treatment of CP could significantly improve the clinical effectiveness[OR=4.50,95%CI(2.35,7.41),P<0.00001],and reduce the prostatic inflammatory symptom index(NIH-CPSI score)[MD=-6.02,95%CI(-7.68,-4.36).P<0.00001],remove white blood cells from prostatic fluid[MD=-7,61,95%CI(-8.47,-6.74),P<0.00001],improve the maximum urine flow rate[MD=3.31,95%CI(0.93,5.69),P<0.00001].Conclusion:Qianlie Shutong Capsule combined with tamsulosin hydrochloride in the treatment of CP can significantly improve clinical effectiveness,reduce NIH-CPSI score,clear white blood cells in prostatic fluid,improve maximum urine flow rate and reduce adverse reactions.

关 键 词：慢性前列腺炎 前列舒通胶囊 盐酸坦索罗辛 META分析 

分 类 号：R697.33[医药卫生—泌尿科学]