肾小管上皮细胞程序性死亡在草酸钙结石形成中的作用  

The role of renal tubular epithelial cells programmed death in the mechanism of calcium oxalate stones formation

作　　者：董才韬 廖文彪[1] 杨嗣星[1] Dong Caitao;Liao Wenbiao;Yang Sixing(Department of Urology,People's Hospital of Wuhan University,Wuhan 430061,China)

机构地区：[1]武汉大学人民医院泌尿外科,武汉430061

出　　处：《中华泌尿外科杂志》2024年第6期485-488,共4页Chinese Journal of Urology

基　　金：国家自然科学基金(82070723、82270797)。

摘　　要：草酸钙结石是肾结石最主要的类型。草酸钙晶体或高草酸尿诱导的肾小管上皮细胞损伤和程序性死亡是草酸钙结石形成的关键因素。肾小管上皮细胞程序性死亡可为草酸钙晶体提供附着位点、参与构成结石成分和加剧周边组织损伤。多种细胞程序性死亡模式可同时参与损伤过程,调节其中串联点,有望达到多层级调控。本文就肾小管上皮细胞程序性死亡与草酸钙结石形成机制间的联系,以及不同的程序性死亡模式参与草酸钙结石发病机制的相关研究进行总结和探讨。Calcium oxalate stones are the most common type of kidney stones in China.The injury and death of renal tubular epithelial cells induced by hyperoxaluria or calcium oxalate crystals are the key factors in the formation of calcium oxalate stones.Renal tubular epithelial cell death can provide attachment sites for calcium oxalate crystals,being part of the composition of stones and aggravate tissue damage.Multiple cell programmed death patterns can participate in cell injury and regulate the intersection to achieve multi-level regulation.This article summarized and discussed the relationship between renal tubular epithelial cell programmed death and the mechanism of calcium oxalate stone formation,and the related research of different programmed cell death patterns involved in the pathogenesis of calcium oxalate stones in recentyears.

关 键 词：草酸钙结石 程序性细胞死亡 细胞凋亡 肾小管上皮细胞 

分 类 号：R692.6[医药卫生—泌尿科学]