姜黄素在心肌纤维化中的作用及机制研究进展  

Research progress on the role and mechanism of curcumin in myocardial fibrosis

作　　者：闫保娥 朱敏杰 方敏 韩拓 周静[1] YAN Bao-e;ZHU Min-jie;FANG Min;HAN Tuo;ZHOU Jing(Department of Cardiology,Affiliated Hospital of Yan’an University,Yan’an 716000,Shaanxi,China;Department of Cardiology,Second Affiliated Hospital of Xi'an Jiaotong University,Xi’an 710004,Shaanxi,China)

机构地区：[1]延安大学附属医院心血管内科,陕西延安716000 [2]西安交通大学第二附属医院心血管内科,陕西西安710004

出　　处：《心脏杂志》2024年第4期446-451,共6页Chinese Heart Journal

基　　金：陕西省卫生健康科研基金项目(2022A008);延安大学附属医院科学技术研究发展计划项目(2021PT-06)。

摘　　要：心肌纤维化(myocardial fibrosis,MF)是以心脏成纤维细胞过度增殖、胶原沉积及异常分布为特征的心脏间质重构,可见于高血压、心肌梗死、心力衰竭等多种心血管疾病。MF是心肌重构的主要表现,可导致心肌僵硬度增加、心室舒张功能障碍、冠状动脉储备下降甚至引起心源性猝死。姜黄素是传统中药姜黄、莪术、郁金中多酚类活性成分,近年来被报道具有抗炎、抗氧化、改善纤维化作用。本研究综述姜黄素在心肌纤维化中的作用及最新研究机制,为姜黄素临床治疗应用提供参考依据。Myocardial fibrosis(MF)is an interstitial remodeling of myocardium characterized by excessive proliferation of cardiac fibroblasts,collagen deposition and abnormal distribution,which could be seen in various cardiovascular diseases such as hypertension,myocardial infarction and heart failure.MF is the main manifestation of myocardial remodeling,which could lead to increased myocardial stiffness,ventricular diastolic dysfunction,decreased coronary flow reserve and even sudden cardiac death.Curcumin,the polyphenols extracted from traditional Chinese medicines such as Curcuma,Zedoary and Turmeric,has been reported to exert anti-inflammatory,antioxidant and anti-fibrosis effects in recent years.Here we review the latest research of the role and mechanism of curcumin in myocardial fibrosis,thus to provide a scientific basis for the clinical application of curcumin.

关 键 词：心肌纤维化 姜黄素 肾素-血管紧张素系统 转化生长因子Β 基质金属蛋白酶 

分 类 号：R542.2[医药卫生—心血管疾病]