Zinc(Ⅱ)metal-organic framework eluting titanium implant as propulsive agent to boost the endothelium regeneration  

作　　者：Wen Liu Xiaoyu Wang Ying Li Shihai Xia Wencheng Zhang Yakai Feng 

机构地区：[1]School of Chemical Engineering and Technology,Tianjin University,Tianjin 300350,China [2]College of Materials Science and Engineering,Qingdao University,Qingdao 266071,China [3]Department of Hepatopancreatobiliary and Splenic Medicine,Affiliated Hospital,Logistics University of People’s Armed Police Force,Tianjin 300162,China [4]Department of Physiology and Pathophysiology,Logistics University of Chinese People’s Armed Police Force,Tianjin 300309,China [5]Frontiers Science Center for Synthetic Biology,Tianjin University,Tianjin 300072,China [6]Key Laboratory of Systems Bioengineering(Ministry of Education),Tianjin University,Tianjin 300072,China

出　　处：《Frontiers of Chemical Science and Engineering》2024年第6期123-131,共9页化学科学与工程前沿（英文版）

基　　金：supported by National Natural Science Foundation of China (Grant No.52373151).

摘　　要：The advent of antiproliferative drug-eluting vascular stents can dramatically reduce in-stent restenosis via inhibiting the hyperproliferation of vascular smooth muscle cells.However,the antiproliferative drugs also restrain the repair of the injured endothelial layer,which in turn leads to the very later in-stent restenosis.Evidence points that competent endothelium plays a critical role in guaranteeing the long-term patency via maintaining vascular homeostasis.Boosting the regeneration of endothelium on the implanted vascular stents could be rendered as a promising strategy to reduce stent implantation complications.In this regard,bioactive zinc(II)metal-organic framework modified with endothelial cell-targeting Arg-Glu-Asp-Val peptide was embedded in poly(lactide-co-caprolactone)to serve as a functional coating on the surface of titanium substrate,which can promote the proliferation and migration of endothelial cells.The in vitro cell experiments revealed that the zinc(II)metal-organic framework embedded in the polymer coating was able to modulate the behaviors of endothelial cells owing to the bioactive effects of zinc ion and peptide.Our results confirmed that zinc(II)metal-organic framework eluting coating represented a new possibility for promoting the repair of the damaged endothelium with potential clinical implications in vascular-related biomaterials and tissue engineering applications.

关 键 词：Zinc(II)metal-organic framework vascular stent REDV peptide endothelium regeneration coating 

分 类 号：O643.36[理学—物理化学] TB332[理学—化学]