卵巢正常反应人群拮抗剂方案单用高纯度尿促性素促排卵的临床效果  

Effect of highly purified hMG on ovulation induction in normal ovarian responder patients with antagonist protocol

作　　者：徐千花[1,2,3,4,5] 曹云霞 曾娟[1,2,3,4,5] Xu Qianhua;Cao Yunxia;Zeng Juan(Dept of Obstetrics and Gynecology,The First Affiliated Hospital of Anhui Medical University,Hefei 230032;NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract,Hefei 230032;Key Laboratory of Birth Health of Ministry of Education,Hefei 230032;Anhui Province Key Laboratory of Reproductive Health and Genetics,Hefei 230032;Anhui Provincial Engineering Technology Research Center for Biopreservation and Artificial Organs,Hefei 230032)

机构地区：[1]安徽医科大学第一附属医院妇产科,合肥230032 [2]国家卫生健康委配子及生殖道异常研究重点实验室,合肥230032 [3]出生人口健康教育部重点实验室,合肥230032 [4]生殖健康与遗传安徽省重点实验室,合肥230032 [5]安徽省生命资源保存与人工器官工程技术研究中心,合肥230032

出　　处：《安徽医科大学学报》2024年第6期966-970,共5页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:82301864);生殖健康与遗传安徽省重点实验室开放课题基金(编号:RHG-2021-1)。

摘　　要：目的比较卵巢正常反应人群(NOR)拮抗剂方案中单用高纯度尿促性素(HP-hMG)与重组人卵泡刺激素(rFSH)促排卵的临床结局。方法回顾性收集行NOR拮抗剂助孕的患者,根据拮抗剂方案中采用超促排卵药物的不同,分为HP-hMG组和rFSH组。统计两组患者基本信息、促排卵情况、实验室指标以及临床结局等指标。结果最终纳入614例NOR患者:HP-hMG组(n=216),rFSH组(n=398)。两组间hCG注射日P及LH水平差异无统计学意义,HP-hMG组hCG注射日E2水平显著降低(P<0.001);HP-hMG组生化妊娠率(69.23%vs 63.51%)以及临床妊娠率(66.67%vs 59.46%)较rFSH组有升高的趋势。HP-hMG组卵巢过度刺激综合征(OHSS)发生率(2.31%vs 3.02%)较rFSH组有降低趋势。结论对于NOR接受拮抗剂方案助孕的患者,与采用rFSH相比,单独使用HP-hMG能够获得同样较好的临床妊娠率,并在降低OHSS发生率方面具有一定优势。Objective To compare the differences in clinical outcomes of ovulation induction with highly purified human menopausal gonadotropin(HP-hMG,Menopur)versus recombinant human follicle stimulating hormone(rFSH,Gonal-F)in normal ovarian responder patients treated with the GnRH-antagonist protocol.Methods Patients treated with the GnRH-antagonist protocol were retrospectively analyzed and divided by gonadotropin(Gn)usage into HP-hMG group and rFSH group.The basic characteristics,ovulation induction method,laboratory indexes,and clinical outcomes were compared between the two groups.Results A total of 614 normal ovarian responder patients were enrolled in the study,with 216 in the HP-hMG group and 398 in the rFSH group.There was no significant difference in P levels and LH levels on the hCG trigger day between the two groups.However,the E 2 levels on the hCG trigger day were significantly lower in the HP-hMG group(P<0.001).Moreover,the HP-hMG group had a higher biochemical pregnancy rate(69.23%vs 63.51%)and clinical pregnancy rate(66.67%vs 59.46%)compared to the rFSH group.The incidence of OHSS in the HP-hMG group(2.31%vs 3.02%)showed a decreasing trend compared to the rFSH group.Conclusion Compared to rFSH,HP-hMG offers distinct advantages in reducing the incidence of OHSS and improving pregnancy outcomes in normal ovarian responder patients undergoing pituitary suppression with the GnRH-antagonist protocol.

关 键 词：卵巢正常反应人群 高纯度尿促性素 重组人卵泡刺激素 体外受精-胚胎移植 控制性超促排卵 

分 类 号：R711.6[医药卫生—妇产科学]