亚低温联合药物治疗新生儿缺氧缺血性脑病的研究进展  

Progress on the treatment of neonatal hypoxic-ischemic encephalopathy with combination of therapeutic hypothermia and drugs

作　　者：徐晓芳 刘春丽[1] 张亚昱[1] Xu Xiaofang;Liu Chunli;Zhang Yayu(Department of Neonatology,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学附属医院新生儿科,呼和浩特010050

出　　处：《国际儿科学杂志》2024年第5期335-340,共6页International Journal of Pediatrics

基　　金：内蒙古自治区自然科学基金项目(2021LHMS08044)。

摘　　要：新生儿缺氧缺血性脑病(hypoxic-ischemic encephalopathy,HIE)是一种由于围生期窒息导致的缺氧和脑血流减少而引发的新生儿脑损伤疾病, 其在全球的发病率较高, 也是导致婴幼儿死亡的主要原因之一。积极治疗HIE可减少脑损伤, 提升HIE患儿生活质量。近年来亚低温疗法是临床公认的效果较好的HIE治疗方法, 其可改善足月儿中重度HIE的生存率并显著降低致残率, 但治疗的成功率相对较低, 大约有40%~55%的患儿在接受亚低温治疗后, 仍然可能面临中到重度的神经发育问题。因此, 利用亚低温和神经保护性药物联合治疗新生儿HIE的方法正受到越来越多的关注, 该治疗方法能进一步减轻缺氧缺血性脑损伤的程度, 改善临床症状, 提高神经行为能力, 缓解缺氧缺血性脑损伤导致的神经发育障碍, 为未来探索更多HIE神经保护疗法提供新思路。Hypoxic-ischemic encephalopathy(HIE)is a neonatal brain injury disease caused by hypoxia and reduced cerebral blood flow due to perinatal asphyxia.Its incidence rate is quite high,and it is also one of the main factors leading to infant death.Effective treatment of HIE can reduce brain damage and improve the prognosis.In recent years,therapeutic hypothermia has been clinically recognized as an effective treatment for HIE,which can improve the survival rate of full-term infants with moderate to severe HIE and significantly reduce disability rates.However,the effective rate of the treatment is relatively low,with approximately 40%to 55%of children still facing moderate to severe neurodevelopmental sequela after therapeutic hypothermia.Therefore,a combination treament of HIE with neuroprotective drugs has been paid more attention.This treatment method further reduces the severity of hypoxic-ischemic brain injury,improves clinical symptoms,enhances neurological behavior,and alleviates neurodevelopmental disorders caused by hypoxic-ischemic brain injury,providing new ideas for exploring more neuroprotective therapies for HIE in the future.

关 键 词：新生儿 缺氧缺血性脑病 亚低温治疗 神经保护性药物 

分 类 号：R722.1[医药卫生—儿科]