经鼻内镜手术治疗嗅神经母细胞瘤的临床分析  

Clinical analysis of endonasal endoscopic surgery in esthesioneuroblastoma

作　　者：顾月龙 茆松 唐如 李志鹏 张维天 GU Yuelong;MAO Song;TANG Ru;LI Zhipeng;ZHANG Weitian(Department of Otolaryngology Head and Neck Surgery,Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital,Shanghai,200233,China)

机构地区：[1]上海交通大学医学院附属第六人民医院耳鼻咽喉头颈外科,上海200233

出　　处：《临床耳鼻咽喉头颈外科杂志》2024年第6期503-507,共5页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：国家自然科学基金(No:82071014,82271137)。

摘　　要：目的探讨嗅神经母细胞瘤的临床特点和经鼻内镜手术联合放/化疗的治疗效果。方法回顾性分析2009年9月—2023年6月我院收治的接受经鼻内镜手术治疗的17例嗅神经母细胞瘤患者的临床、手术资料及随访结果。结果17例患者中改良Kadish B期4例,C期10例,D期3例。10例患者一期行鼻内镜手术切除肿瘤(除外颈清),平均手术时长(5.2±2.5)h,平均出血量为(192.0±162.0)mL。15例患者行颅底重建,3例患者出现术后并发症,13例患者达到阴性切缘。所有患者均得以随访,平均随访(49.7±40.2)个月,死亡3例,复发和(或)转移6例。1、2和5年总体生存率分别为88.2%、80.2%和80.2%,1、2和5年无病生存率分别为82.4%、82.4%和50.8%。切缘阴性和切缘阳性的患者2年总体生存率分别为100.0%和25.0%,2年无病生存率分别为61.5%和25.0%。结论经鼻内镜手术联合放/化疗治疗嗅神经母细胞瘤疗效可靠,切缘阳性患者预后较差。Objective To investigate the clinical characteristics of esthesioneuroblastoma and the efficacy of endonasal endoscopic surgery combined with radiotherapy/chemotherapy.Methods The clinical and surgical data of 17 patients with esthesioneuroblastoma who underwent endonasal endoscopic surgery in our department from September 2009 to June 2023 were retrospectively analyzed.Results Among all patients,the modified Kadish stage B was identified in 4 patients,C in 10 patients,and D in 3 patients.Ten of them underwent endonasal endoscopic surgery without neck dissection in one day,whose average operation time is(5.2±2.5)hours and average blood loss is(192±162)mL.Skull base reconstructions were performed in 15 patients,postoperative complications were observed in 3 patients,and negative margins were obtained in 13 patients.All 17 patients were followed up for an average of(49.7±40.2)months.Three patients died and 6 had recurrence and/or metastasis.The 1-year,2-year and 5-year overall survival rates were 88.2%,80.2%,and 80.2%,respectively,and the 1-year,2-year and 5-year disease-free survival rates were 82.4%,82.4%,and 50.8%,respectively.The 2-year overall survival rates of patients with negative and positive margins were 100%and 25%,respectively,while the 2-year disease-free survival rates were 61.5%and 25.0%,respectively.Conclusion Endonasal endoscopic surgery combined with radiotherapy/chemotherapy can achieve satisfactory effect in esthesioneuroblastoma,and the prognosis of patients with positive margins is poor.

关 键 词：嗅神经母细胞瘤 鼻内镜 外科手术 预后 

分 类 号：R763.9[医药卫生—耳鼻咽喉科]