乳腺近红外光谱断层成像系统研究进展  

Research Progress in Near Infrared Spectral Tomography for Breast

作　　者：魏承朴 冯金超 栗雅轩 胡婷 孙中华 贾克斌 李哲 Wei Chengpu;Feng Jinchao;Li Yaxuan;Hu Ting;Sun Zhonghua;Jia Kebin;Li Zhe(Beijing Key Laboratory of Computational Intelligence and Intelligent System,Faculty of Information Technology,Beijing University of Technology,Beijing 100124,China;Beijing Laboratory of Advanced Information Networks,Beijing 100876,China)

机构地区：[1]北京工业大学信息学部计算智能与智能系统北京市重点实验室,北京100124 [2]先进信息网络北京实验室,北京100876

出　　处：《中国激光》2024年第9期143-159,共17页Chinese Journal of Lasers

基　　金：国家自然科学基金(82171992,62105010);北京市科技新星计划(20230484448)。

摘　　要：近红外光谱断层成像是一种可以获得乳腺组织内部光学特性,弥补传统乳腺影像学检查方法的不足,具有无创无辐射、高特异性等特性,在乳腺成像中有重要应用价值的光学成像技术。近红外光谱断层成像系统对该技术在乳腺疾病临床诊断中的应用起着重要的作用。然而,近红外光谱断层成像系统的空间分辨率低,限制了其在乳腺成像中的应用。将连续波模式与频域或时域测量模式相结合,并融合临床用的数字乳腺断层摄影、超声或核磁共振成像等技术有助于解决上述问题。先对近红外光谱断层成像系统的测量模式、多模态系统和多模态融合技术进行梳理、对比,然后介绍了该技术在乳腺成像中的最新应用,进一步讨论了乳腺近红外光谱断层成像系统未来的发展方向。Significance Breast cancer is the most common cancer diagnosed among women worldwide,which accounts for 11.7%of all new cancer diagnoses in 2020.Breast cancer mortality rates decrease significantly when breast tumor is detected early using imaging tools.As an emerging imaging technique,near-infrared spectral tomography(NIRST)has demonstrated potential in breast imaging owing to its nonionizing radiation and high sensitivity and cost-effectiveness.The aim of NIRST is to resolve three-dimensional images of tissue optical properties and chromophore concentrations from acquired multi-wavelength measurements.Therefore,functional information related to biological tissue can be obtained,which is indistinguishable using current clinical breast-imaging modalities.However,NIRST exhibits poor spatial resolution because of light scattering in biological tissues.NIRST system is the key ingredient for producing NIRST images of high spatial resolution.In recent decades,various techniques have been adopted to improve NIRST system performance,which can facilitate the use of NIRST in breast cancer detection,diagnosis,and treatment.The purpose of this study is to review the current progress on NIRST systems and summarize their advantages and limitations.We also report recent clinical applications of NIRST systems in breast imaging and discuss the challenges and future developments.Progress This paper presents a review of imaging types(Fig.2)involved in data acquisition.First,continuous wave(CW)systems,including available commercial instruments,are introduced(Fig.3).The widely used frequency-domain(FD)and time-domain(TD)systems are summarized(Figs.4 and 5).The emerging hybrid imaging types and relevant prototype systems are also reviewed(Fig.6).The integration of conventional breast cancer-imaging systems into NIRST can enhance spatial resolution of NIRST and improve lesion characterization.Therefore,the multimodality imaging systems widely used in breast imaging are also reported(Figs.7 and 8),particularly in magnetic resonance ima

关 键 词：成像系统 生物光学 近红外光谱断层成像 乳腺成像 多模态 

分 类 号：TN29[电子电信—物理电子学]