石墨烯柔性生物传感技术与可穿戴式精准医疗健康监护应用  

Graphene-based Flexible Biosensing Technology and Wearable Precision Medical-Health-Monitoring Application

作　　者：杨晗 王铈弘 钟豪 黄乐阳 赵建鑫 吕文琦 毛则尹 邓安妮 石艺璇 黄琴[1] 王一璐 黄国亮[1] Yang Han;Wang Shihong;Zhong Hao;Huang Leyang;Zhao Jianxin;Lu Wenqi;Mao Zeyin;Deng Anni;Shi Yixuan;Huang Qin;Wang Yilu;Huang Guoliang(Department of Biomedical Engineering,Tsinghua University,Beijing 100084,China)

机构地区：[1]清华大学生物医学工程学院,北京100084

出　　处：《中国激光》2024年第9期215-226,共12页Chinese Journal of Lasers

基　　金：国家自然科学基金(61927819,81827808,62105177,62375148);国家重点研发计划(2018YFA0704000);四川省科技计划重点项目(2021YFQ0060,2022YFS0637);北京实验室基金与清华大学自主科研基金(20194180031,20201080058,20201080510);万科公共卫生与健康学科发展专项基金(2022Z82WKJ002)。

摘　　要：可穿戴柔性电子技术是医疗健康监测,尤其是心血管疾病监测的重要发展方向之一。脉搏波是评估心血管健康的重要信息来源,但它属于非平稳弱信号,对检测端的灵敏度与稳定性具有较高要求。为解决可穿戴健康监测的柔性传感关键技术问题,设计并开发了具有多级分支微结构的石墨烯柔性压力传感器,显著提高了对脉搏波的传感性能,并构建了可穿戴柔性传感脉搏波健康监测系统,建立了基于单点桡动脉脉搏波和Transformer架构的类感知无袖带血压监测算法,对人体收缩压和舒张压的预测误差分别为(0.7±10.5)mmHg和(0.5±6.1)mmHg。本工作可以为心血管健康动态监测系统与应用研究、可穿戴式精准医疗健康监护提供重要技术支持。Objective Wearable flexible electronics is one of the development trends in medical-health monitoring,particularly cardiovascular-disease monitoring.Pulse wave is an important source of information for assessing cardiovascular health;however,it is a non-stationary weak signal and imposes high requirements on the sensitivity and stability of detection.To solve the key technical problems of wearable health monitoring,a graphene-based flexible pressure sensor with a multilevel branched microstructure is designed and developed in this study,which significantly improves the sensing performance of pulse waves and forms the foundation for a wearable flexible pressure sensor.The sensing health-monitoring system is developed using a sensing-like cuffless blood-pressure-monitoring algorithm based on single-point radial artery pulse waves.The prediction errors of the system for human systolic blood pressure(SBP)and diastolic blood pressure(DBP)are(0.7±10.5)mmHg and(0.5±6.1)mmHg,respectively.The findings of this study can provide important technical support for cardiovascular health-monitoring systems and application research,as well as for wearable precision medical-health monitoring.Methods Flexible pressure sensors based on array structures exhibit key technical issues such as difficulty in achieving high sensitivity and a wide pressure-detection range,as well as limited usage.Hence,a hierarchical branch(HB)structure pressure-sensor design scheme is proposed in this study to improve the performance of array-microstructure pressure sensors.First,we completed the design of the HB structure via finite-element analysis.Results of the finite-element analysis reveal the unique effect of the HB structure:it not only includes the elastic-modulus-reduction effect caused by the superposition of multiple elastic layers but also integrates the pressure-diffusion effect caused by the HB structure,thus realizing the gradual activation and further strengthening of the active-layer conduction path.As such,the deformation range of the e

关 键 词：石墨烯柔性压力传感器 脉搏波 可穿戴设备 无袖带血压测量 

分 类 号：O436[机械工程—光学工程]