花粉-食物过敏综合征诊断及管理专家共识  

Expert consensus on the diagnosis and management of pollen-food allergy syndrome

作　　者：中华医学会变态反应学分会过敏原特异性诊断学组 福棠儿童医学发展研究中心过敏(变态)反应学科规范化建设研究组 北京慢性病防治与健康教育研究会变态反应学专业委员会 中国老年保健协会过敏性疾病分会 关凯 向莉[3] 姜楠楠 李丽莎 Allergen Specific Diagnostics Group,Chinese Society of Allergology,Chinese Medical Association;The Group of Standardized Construction for Allergic Diseases,Futang Research Center of Pediatric Development;Committee on Allergy,Beijing Research Association for Chronic Diseases Control and Health Education;Committee on Allergy,Chinese Aging Well Association;Guan Kai;Xiang Li(不详;Department of Allergy,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Disease,National Clinical Research Center for Dermatologic and Immunologic Diseases,Beijing 100730,China;Department of Allergy,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Key Laboratory of Major Diseases in Children,Ministry of Education,National Clinical Research Center for Respiratory Diseases,Beijing 100045,Chin)

机构地区：[1]不详 [2]中国医学科学院北京协和医学院北京协和医院变态(过敏)反应科,过敏性疾病精准诊疗研究北京市重点实验室,国家皮肤与免疫疾病临床医学研究中心,北京100730 [3]国家儿童医学中心,首都医科大学附属北京儿童医院过敏反应科,儿童重大疾病研究教育部重点实验室,国家呼吸系统疾病临床医学研究中心,北京100045

出　　处：《中华预防医学杂志》2024年第6期719-734,共16页Chinese Journal of Preventive Medicine

基　　金：国家呼吸系统疾病临床医学研究中心“呼吸专项”(HXZX-20210203,HXZX-20210204,HXZX-202107);国家自然科学基金面上项目(82370041,82070033);中国医学科学院医学与健康科技创新工程项目(2021-I2M-1-107);北京市研究型病房建设示范单位项目(BCRW202101);中央高水平医院临床科研业务费(2022-PUMCH-B-088,2022-PUMCH-B-089);2023年北京市重大疑难疾病中西医协同攻关项目(儿童肺系过敏性疾病-中西医协同攻关示范项目)(2023BJSZDYNJBXTGG-005)。

摘　　要：花粉-食物过敏综合征(pollen-food allergy syndrome,PFAS)是发生在花粉过敏个体的食物过敏反应。近年来,花粉过敏发病率逐年升高且呈现低龄化趋势,PFAS在国内也逐渐受到关注。PFAS的临床特征具有明显的地域差异及异质性。目前,国内对PFAS诊断手段有限,认识不足,尚无可供临床使用的诊断标准。与原发性食物过敏的管理有所不同,PFAS管理需要同时兼顾花粉过敏和食物过敏,管理具有特殊性和复杂性,医生在临床实践中管理存在差异。本共识基于目前国内外现有的指南和我国相关研究证据,制定了诊断标准和管理流程图,旨在规范我国PFAS诊治流程,提高诊疗水平,指导变态反应科医师、相关专业医师和全科医师正确认识、诊断及规范管理PFAS。Pollen-food allergy syndrome(PFAS)is a unique type of food allergy that specifically affects individuals with pollen allergy.In recent years,pollen allergy is increasingly and shows younger tendency.PFAS has also become a topic of interest in China.The characteristics of PFAS vary across regions and show obviously heterogeneity due to different pollen sensitization profile.Currently,diagnostic methods for PFAS in China are limited,which may lead to underdiagnosed and underrecognized of this syndrome,there are currently no accessible diagnostic criteria and procedures for clinical use.Unlike primary food allergy,the management of PFAS need a combined strategy which involves managing both pollen allergy and food allergy.Therefore,its management is particularly complex and varies among doctors in clinical practice.This consensus has developed a diagnosis and management flow chart based on current domestic and foreign guidelines,as well as relevant research evidence in China.The aim is to improve the standard diagnosis and treatment of PFAS and provide guidance to allergists,healthcare professionals,and general practitioners for accurate understanding,diagnosis,and standardized management of PFAS.

关 键 词：食物过敏 花粉过敏 专家共识 花粉-食物过敏综合征 口腔过敏综合征 

分 类 号：R593.1[医药卫生—内科学]