2023欧洲变态反应和临床免疫学会IgE介导食物过敏诊断指南的解读  

Interpretation of 2023 EAACI guidelines on the diagnosis of IgE-mediated food allergy

作　　者：姜楠楠 向莉[1] Jiang Nannan;Xiang Li(Key Laboratory of Major Diseases in Children,Ministry of Education,Department of Allergy,Beijing Children′s Hospital,Capital Medical University,National Center for Children′s Health,Beijing 100045,China)

机构地区：[1]国家儿童医学中心,首都医科大学附属北京儿童医院过敏反应科,儿科重大疾病研究教育部重点实验室,北京100045

出　　处：《中华预防医学杂志》2024年第6期735-744,共10页Chinese Journal of Preventive Medicine

基　　金：国家呼吸系统疾病临床医学研究中心“呼吸专项”(HXZX-20210203,HXZX-20210204,HXZX-202107);北京市研究型病房建设示范单位项目(BCRW202101);2023年北京市重大疑难疾病中西医协同攻关项目(儿童肺系过敏性疾病-中西医协同攻关示范项目)(2023BJSZDYNJBXTGG-005)。

摘　　要：食物过敏患病率在全球范围内呈逐年上升趋势,已成为重要的公共卫生问题之一,严重影响患者及家庭的生活质量。目前食物过敏诊断不足及诊断过度现象均存在。食物过敏的精准诊断及基于精准诊断进行个体化规范管理至关重要。自2014年欧洲变态反应和临床免疫学会(EAACI)发布食物过敏指南以来,近年来,食物过敏诊断,尤其是IgE介导食物过敏诊断方法,如过敏原组分诊断及嗜碱性粒细胞活化试验等相关研究陆续发表,EAACI于2023年10月更新发表IgE介导食物过敏诊断指南。为加强变态反应专科医师和相关专业医师理解最新EAACI关于IgE介导食物过敏诊断的建议和推荐,现将该指南进行详细解读。The prevalence of food allergy is increasing globally,becoming a significant public health issue that greatly impacts the quality of life for patients and their families.However,there is currently a problem with both underdiagnosis and overdiagnosis of food allergy.Therefore,accurate diagnosis of food allergy and personalized management based on accurate diagnosis are crucial.Over the past 10 years,there has been relevant research on food allergy diagnosis,particularly focusing on IgE-mediated food allergy diagnostic methods such as component resolved diagnosis and basophil activation test,since the launch of the European Academy of Allergy and Clinical Immunology(EAACI)Food Allergy Guidelines in 2014.In October 2023,EAACI published updated diagnostic guidelines for IgE-mediated food allergy.To help allergists and other medical professionals stay informed about the latest EAACI recommendations on the diagnosis of IgE-mediated food allergy,this guideline is now being interpreted.

关 键 词：嗜碱性粒细胞活化试验 诊断 食物过敏 口服激发试验 皮肤点刺试验 特异性IGE 

分 类 号：R593.1[医药卫生—内科学]