口服耐受诱导疗法预防婴幼儿鸡蛋过敏的研究进展  

The advances on oral tolerance induction for prevention of egg allergy in infants

作　　者：柴圆圆 钱华[1] Chai Yuanyuan;Qian Hua(Department of Dermatology,Children′s Hospital of Soochow University,Suzhou 215000,China)

机构地区：[1]苏州大学附属儿童医院皮肤科,苏州215000

出　　处：《中华预防医学杂志》2024年第6期763-767,共5页Chinese Journal of Preventive Medicine

摘　　要：食物过敏的患病率逐年升高,严重影响了患者及其家庭的生活质量。其中鸡蛋是主要过敏原的一种,传统的预防鸡蛋过敏的方法是延迟在婴儿辅食中添加鸡蛋,但这种方法并不能降低鸡蛋过敏的患病率,反而可能会影响婴儿的身心健康。口服耐受疗法是通过主动抑制胃肠道对于抗原的特异性反应而建立免疫耐受的过程。目前多项研究表明通过早期引入鸡蛋诱导口服耐受可以预防鸡蛋过敏,并已被纳入许多国家的婴儿喂养指南。本文在此主要阐述口服耐受诱导疗法在预防鸡蛋过敏中的机制、疗效及安全性。The prevalence of food allergy is increasing worldwide and seriously affects the living quality of patients and their families.Egg allergy is one of the commonest forms of food allergy.The traditional regimen is to delay the introduction of eggs to infant complementary foods,which is not able to reduce the prevalence of egg allergies and causes negative effects on infants′physical and psychological conditions.Oral tolerance therapy is an approach to establish immune tolerance by the active suppression of specific immune responses to antigens in the gastrointestinal tract.The development of oral tolerance through early introduction of eggs to infant complementary has proven effective in randomized controlled trials,which has been incorporated into infant feeding guidelines in many countries.This article focuses on the mechanism,efficacy and safety of oral tolerance induction in the prevention of egg allergy.

关 键 词：鸡蛋过敏 口服耐受诱导 疗效 安全性 

分 类 号：R725.9[医药卫生—儿科]