孕期主要持久性有机污染物暴露对儿童神经系统功能发育影响的研究进展  

Research progress on the effects of exposure to major persistent organic pollutants during pregnancy on the functional development of nervous system in children

作　　者：吴舒琪 刘博蕊 杨喆 郑璐[1] 王小川 杨昕悦 贾丽红[2] 胡嘉晋 Wu Shuqi;Liu Borui;Yang Zhe;Zheng Lu;Wang Xiaochuan;Yang Xinyue;Jia Lihong;Hu Jiajin(Key Laboratory of Obesity and Glucose,Lipid Associated Metabolic Diseases of Liaoning Province/Health Sciences Institute,China Medical University,Shenyang 110122,China;School of Public Health,China Medical University,Shenyang 110122,China)

机构地区：[1]辽宁省肥胖与糖脂代谢性疾病重点实验室,中国医科大学健康科学研究院,沈阳110122 [2]中国医科大学公共卫生学院,沈阳110122

出　　处：《中华预防医学杂志》2024年第6期917-923,共7页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金(82103860)。

摘　　要：持久性有机污染物(POPs)具有抵抗环境降解性、生物蓄积性和远距离迁移潜力等特点,母亲孕期POPs暴露可通过胎盘屏障进入胎儿血液循环,对子代的神经系统功能发育产生潜在影响,进而导致成人期神经系统功能缺陷和疾病的发生发展。本文旨在阐明孕期暴露于3种主要POPs(有机氯化合物、全氟及多氟烷基物质和多溴联苯醚)对儿童神经系统功能发育(社会情绪、认知、语言、运动和适应性)的影响,为后续相关研究提供参考依据。Persistent Organic Pollutants(POPs)have the characteristics of resistance to environmental degradation,bioaccumulation and long-distance migration potential.Maternal exposure to POPs during pregnancy can enter the fetal blood circulation through the placental barrier,and have a potential impact on the functional development of the nervous system of the offspring.This in turn leads to the occurrence and development of neurological defects and diseases in adulthood.The purpose of this paper is to elucidate the effects of exposure to three major POPs(organochlorine compounds,perfluoroalkyl and polyfluoroalkyl substances,and polybrominated diphenyl ethers)during pregnancy on the functional development of the nervous system(social emotions,cognition,language,exercise,and adaptability)in children,and to provide reference for subsequent studies.

关 键 词：持久性有机污染物 神经系统功能 儿童发育 宫内暴露 综述 

分 类 号：R715[医药卫生—妇产科学] R114[医药卫生—临床医学]