健康中老年人肾功能、脑功能连接及认知功能的相关性  

Correlations Among Kidney Function,Brain Functional Connectivity and Cognitive Function in Healthy Middle Aged and Elderly People

作　　者：李雨晴 李慧[1] 朱婉秋 汪文睿 叶伟[1] 陆运 李晓舒[1] LI Yuqing;LI Hui;ZHU Wanqiu(Department of Radiology,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui Province 230032,P.R.China)

机构地区：[1]安徽医科大学第一附属医院放射科,合肥230032

出　　处：《临床放射学杂志》2024年第6期1021-1025,共5页Journal of Clinical Radiology

基　　金：2022年度安徽省高校科研项目重点项目(编号:2022AH051138)。

摘　　要：目的 探索用多模态MRI观察在健康中老年人群中肾功能、脑功能连接(FC)及认知功能之间的相关性。方法 对49名认知正常的健康中老年参与者进行静息态高分辨率MRI扫描和标准化神经心理学评估;基于体素水平行FC分析;采集外周静脉血,检测血清肾功能指标。采用相关性分析和中介分析观察认知功能、肾功能及脑FC的关系。结果 健康老年人的左侧海马和右侧中央前回的FC值与血尿素浓度呈负相关;左侧海马和左侧眶部额中回、右侧楔前叶、右侧眶部额下回、右侧岛盖部额下回、左侧额中回、右侧顶下回的FC值,右侧海马旁回和左侧额中回、双侧眶部额下回、右侧枕上回、左侧距状裂周围皮层、右侧顶下缘角回、左侧楔前叶、左侧中央前回、双侧颞上回的FC值与尿酸呈负相关(r=-0.546~-0.724,P均<0.05)。左侧海马和左侧眶部额中回的FC值与词语流畅性测验(VFT)呈负相关(r=-0.388,P=0.008)。中介分析发现左侧海马和左侧眶部额中回的FC可部分介导尿酸对VFT的效应,中介效应值0.0265[95%CI(0.0062,0.0581)]。结论 在健康中老年人中肾功能水平与认知功能及脑FC间存在一定的相关性。Objective To explore the correlation among kidney function,brain functional connectivity,and cognitive function in healthy middle aged and elderly people observed with multimodal MRI.Methods Resting-state high-resolution MRI scans with standardized neuropsychological assessment were acquired from 49 healthy middle aged and elderly volunteers with normal cognitive function.Functional connectivity(FC)analysis was performed based on voxel levels.Peripheral venous blood was collected and serum kidney function indices were measured.Correlation and mediation analysis were used to observe the relationship among kidney function,brain FC and cognitive function.Results The FC values between the left hippocampus and the right precentral gyrus of healthy older adults was negatively correlated with the concentration of urea;The FC values between the left hippocampusand left middle frontal gyrus,orbital part,right precuneus,right inferior frontal gyrus,orbital part,right inferior frontal gyrus,opercular part,left middle frontal gyrus,and right inferior parietal gyrus,between the right parahippocampal gyrus and left middle frontal gyrus,bilateral inferior frontal gyrus,orbital part,right superior occipital gyrus,calcarine fissure and surrounding cortex,right inferior parietal,but supramarginal and angular gyri,left precuneus,left precentral gyrus,bilateral superior temporal gyrus were negatively correlated with uric acid(r=-0.546-0.724,all P<0.05).The FC value between the left hippocampus and middle frontal gyrus,orbital part was negatively correlated with verbal fluency test(VFT)(r=-0.388,P=0.008).Further mediation analysis showed that the FC between the left hippocampus and middle frontal gyrus,orbital part partially mediated the effect of uric acid on VFT with a mediating effect value of 0.0265[95%CI(0.0062,0.0581)].Conclusion Kidney function,brain functional connectivity and cognitive function have certain correlations in healthy middle aged and elderly people.

关 键 词：中老年人 肾功能指标 脑功能连接 脑-肾轴 认知功能 

分 类 号：R692[医药卫生—泌尿科学] R749.1[医药卫生—外科学]