2022-2023年常熟市急性呼吸道感染病例常见病毒病原谱系分析  

Analysis of common viral pathogen spectrum of acute respiratory infection cases in Changshu city from 2022 to 2023

作　　者：关亚柯 周正元[2] 梅国勇 高晋懿 杜海军[1] 韩俊[1] 徐翠玲[1] Guan Yake;Zhou Zhengyuan;Mei Guoyong;Gao Jinyi;Du Haijun;Han Jun;Xu Cuiling(National Key Laboratory of Traceability and Intelligent Decision-Making for Infectious Diseases,National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China;Changshu Center for Disease Control and Prevention,Changshu 215500,China)

机构地区：[1]中国疾病预防控制中心病毒病预防控制所,传染病溯源预警与智能决策全国重点实验室,北京102206 [2]常熟市疾病预防控制中心,常熟215500

出　　处：《中华实验和临床病毒学杂志》2024年第3期252-257,共6页Chinese Journal of Experimental and Clinical Virology

基　　金：国家重点研发计划-人类病毒感染事件综合应对技术体系及标准规范(2022YFC2602402);国家病原微生物资源库(NPRC-32);传染病预防控制国家重点实验室发展基金(2011SKLIDl04)。

摘　　要：目的了解江苏省常熟市急性呼吸道感染(acute respiratory infection,ARI)病例的常见病毒病原谱构成。方法收集2022年1月至2023年10月常熟市5家哨点医院门诊和住院患者的鼻咽拭子样本,采用实时荧光定量聚合酶链式反应的方法检测流感病毒(influenza virus,Flu)、呼吸道合胞病毒(respiratory syncytial virus,RSV)、腺病毒(adenovirus,AdV)、人鼻病毒(human rhinovirus,HRV)、人副流感病毒(human parainfluenza virus,HPIV)、肠道病毒(enterovirus,EV)、人冠状病毒(human coronavirus,HCoV)、人偏肺病毒(human metapneumovirus,HMPV)和人博卡病毒(human bocavirus,HBoV)的核酸。结果1936份ARI病例中,350份(18.1%)病毒核酸检测为阳性。Flu检出率最高,占7.1%,其次为HBoV(3.7%)、AdV(1.9%)和RSV(1.6%)等。病毒检出率在不同年龄组和季节间具有明显差异,2023年3月总病毒检出率最高(47.6%),以Flu为主;Flu呈现春季和冬季单峰流行;HBoV和HCoV流行趋势一致,且前者检出率(5.43%)高于后者(2.45%),均在夏季出现高峰;RSV在秋季出现流行高峰(4.5%)。0~5岁儿童组检出率最高,可达33.3%。结论常熟市2022—2023年ARI病例感染的病毒以Flu、HBoV、AdV、RSV等病毒为主。Objective To investigate the common viral pathogen spectrum of acute respiratory infection(ARI)cases in Changshu city.Methods Nasopharyngeal swab samples from outpatients and inpatients in five sentinel hospitals in Changshu city from January 2022 to October 2023 were collected.Real-time fluorescent quantitative polymerase chain reaction was used to detect the nucleic acids of influenza virus(Flu)and respiratory syncytial virus(RSV),adenovirus(AdV),human rhinovirus(HRV),human parainfluenza virus(HPIV),enterovirus(EV),human coronavirus(HCoV),human metapneumovirus(HMPV),and human bocavirus(HBoV).Results Of the 1936 ARI cases,18.1%(350/1936)were tested positive for viral nucleic acid.Flu had the highest detection rate(7.1%),followed by HBoV(3.7%),AdV(1.9%)and RSV(1.6%).The virus detection rate was significantly different among different age groups and seasons.In March 2023,the total virus detection rate was the highest(47.6%),mainly Flu.Flu showed unimodal prevalence in spring and winter.The prevalence trend of HBoV and HCoV was consistent,and the detection rate of HBoV(5.43%)was higher than that of HCoV(2.45%),both of which peaked in summer.RSV prevalence peaks in autumn(4.5%).The detection rate of children aged 0-5 years was the highest,reaching 33.3%.Conclusions The main ARI pathogens in Changshu city from 2022 to 2023 were Flu,HBoV,AdV and RSV.

关 键 词：急性呼吸道感染 病毒 病原谱 流行病学 

分 类 号：R56[医药卫生—呼吸系统]