中性粒细胞在呼吸道腺病毒感染中的免疫损伤机制  

Mechanisms of neutrophil-mediated injury to respiratory tract by adenovirus infection

作　　者：樊似媛 曾赛珍[1] Fan Shiyuan;Zeng Saizhen(The First Affiliated Hospital of Hunan Normal University(Hunan Provincial People′s Hospital),Changsha 410005,China)

机构地区：[1]湖南师范大学附属第一医院(湖南省人民医院),长沙410005

出　　处：《中华实验和临床病毒学杂志》2024年第3期357-363,共7页Chinese Journal of Experimental and Clinical Virology

基　　金：湖南省卫生健康高层次人才计划财政项(20230508-1033);湖南省卫生健康委员会项目(C202306016954);湖南省人民医院仁术基金项目(RS2022B04)。

摘　　要：人腺病毒(human adenovirus,HAdV)是呼吸道感染的常见病原体。HAdV感染的重症病例,可出现较高的病死率,也可能遗留闭塞性细支气管炎的后遗症,与免疫损伤机制密不可分。早期炎症反应中,中性粒细胞浸润在炎症反应中扮演重要角色。但它是一把双刃剑,在充当机体"保护者"的同时,当其过度激活,将通过细胞内信号转导途径的调控引发呼吸爆发、脱颗粒等,造成局部组织甚至是全身系统的急性或慢性炎症损伤。本综述主要是阐明中性粒细胞在呼吸道HAdV感染中引起的免疫损伤机制,为临床早期干预和用药提供参考依据,以期重症患者在病情早期获益更大以及减少并发症。Human adenovirus(HAdV)is a common pathogen causing respiratory tract infections.Severe cases of HAdV infection clinically present as critical illness,with a potentially high mortality rate,and may also result in the sequelae of obstructive bronchiolitis,closely intertwined with the mechanism of immune injuries.Neutrophil infiltration plays a crucial role in the early inflammatory response.However,it is a double-edged sword as it plays the role of a"protector"for the body.When it is excessively activated,it can trigger respiratory bursts,degranulation,and other cell signaling pathway dysregulation,causing acute or chronic inflammatory damage to local tissues or even the whole body system.This review aims to elucidate the mechanisms of neutrophil-mediated damage to respiratory tract infections caused by HAdV,providing a reference for early clinical intervention and medication,in order to maximize the benefits and reduce complications for critically ill patients in the early stages of the disease.

关 键 词：人腺病毒 中性粒细胞 免疫损伤 

分 类 号：R512.7[医药卫生—内科学]