HBV急性感染相关肝衰竭临床治愈伴HBsAg血清学转换1例报告  

Clinical cure of acute hepatitis B virus infection-related liver failure with HBsAg seroconversion:A case report

作　　者：全栩枫 熊淑娥 周文青 周汝霞 刘嘉[1] 郑昕[1,2] QUAN Xufeng;XIONG Shue;ZHOU Wenqing;ZHOU Ruxia;LIU Jia;ZHENG Xin(Department of Infectious Diseases,Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430022,China;Hubei Jiangxia Laboratory,Wuhan 430200,China)

机构地区：[1]华中科技大学同济医学院附属协和医院感染科,武汉430022 [2]湖北江夏实验室,武汉430200

出　　处：《临床肝胆病杂志》2024年第7期1446-1449,共4页Journal of Clinical Hepatology

基　　金：国家重点研发计划(2022YFC2305100);国家自然科学基金(92169121);中国科学院武汉病毒研究所(JXBS001)。

摘　　要：急性乙型肝炎患者中约1%可进展至急性肝衰竭,75%的HBV相关急性肝衰竭患者需要接受肝移植或死亡。本研究报道1例HBV急性感染相关肝衰竭患者经过抗病毒及对症支持治疗后达到临床治愈和HBsAg血清学转换,并动态监测其外周血免疫学变化特征。About 1%of the patients with acute hepatitis B can progress to acute liver failure,and 75%of the patients with hepatitis B virus(HBV)-related acute liver failure need to undergo liver transplantation or face death.This article reports a patient with HBV infection-related acute liver failure who achieved clinical cure and HBsAg seroconversion after antiviral therapy and symptomatic/supportive treatment,and dynamic monitoring was performed for immunological markers in peripheral blood.

关 键 词：肝功能衰竭 急性 乙型肝炎病毒 免疫 

分 类 号：R512.62[医药卫生—内科学] R575.3[医药卫生—临床医学]