Toward predictable universal genetic circuit design  

作　　者：Yuanli Gao Baojun Wang 

机构地区：[1]College of Chemical and Biological Engineering,Zhejiang University,Hangzhou,China [2]ZJU-Hangzhou Global Scientific and Technological Innovation Center,Zhejiang University,Hangzhou,China [3]School of Biological Sciences,University of Edinburgh,Edinburgh,UK

出　　处：《Quantitative Biology》2024年第2期225-229,共5页定量生物学（英文版）

基　　金：Fundamental Research Funds for the Central Universities,Grant/Award Number:226-2022-00214;National Key R&D Program of China,Grant/Award Number:2023YFF1204500;“Pioneer”and“Leading Goose”R&D Program of Zhejiang,Grant/Award Number:2024C03011;National Natural Science Foundation of China,Grant/AwardNumbers:32271475,32320103001。

摘　　要：In thepast 2decades,synthetic biologists have applied systematic engineering principles to genetic circuit design to devise biological systems with bespoke behaviors,such as Boolean logic gates,signal filters,oscillators,state machines,perceptrons,and genetic controllers[1,2].Following a bottom-up strategy,the genetic circuits are designed by assembling a set of well-characterized biological components,or genetic parts[3],and optimized through the iterative Design-Build-Test-Learn(DBTL)cycles.

关 键 词：circuit predictability genetic circuit design host independent part characterization PORTABILITY 

分 类 号：Q81[生物学—生物工程]