急性呼吸窘迫综合症表型研究的现状与未来  

Current status and future of phenotypic research on acute respiratory distress syndrome

作　　者：何梦菲 赵玉杰[1] 任佳佳 石晶 王岗[1] HE Meng-fei;ZHAO Yu-jie;REN Jia-jia;SHI Jing;WANG Gang(Department of Critical Care Medicine,The Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,China)

机构地区：[1]西安交通大学第二附属医院重症医学科,陕西西安710004

出　　处：《实用医院临床杂志》2024年第4期44-47,共4页Practical Journal of Clinical Medicine

基　　金：陕西省高层次人才特殊支持计划资助项目。

摘　　要：急性呼吸窘迫综合征(ARDS)是一种由肺炎、非肺部感染、创伤、输血、烧伤、误吸或休克等易感危险因素诱发的急性弥漫性炎症性肺损伤,具较高的发病率、死亡率。然而,大量关于ARDS治疗的临床研究并未取得成功。重要的原因之一是ARDS临床和生物学异质性大,单一的治疗方法并不能改善患者的临床预后,而将ARDS这一异质性综合症分为更同质的亚组可能会在识别有效治疗方面取得更多成功。本文旨在对目前ARDS表型分类予以论述,以帮助临床工作者更好地识别并理解ARDS表型,并进一步予以精准个体化治疗,改善ARDS患者预后。Acute respiratory distress syndrome(ARDS)is a kind of acute diffuse inflammatory lung injury induced by susceptible risk factors such as pneumonia,non-pulmonary infection,trauma,blood transfusion,burns,aspiration or shock.It has high morbidity and mortality.However,a large number of clinical studies on ARDS treatment have not been successful.One of the important reasons is that ARDS is clinically and biologically heterogeneous.A single treatment approach does not improve the clinical prognosis of patients.However,dividing this heterogeneous syndrome into more homogeneous subgroups may lead to greater success in identifying effective treatments.This paper aims to discuss the current classification of ARDS phenotypes.It is to help clinicians better identify and understand the phenotypes of ARDS and further provide accurate individualized treatment to improve the prognosis of ARDS patients.

关 键 词：急性呼吸窘迫综合征 表型 个体化治疗 

分 类 号：R563.8[医药卫生—呼吸系统]