中性粒细胞弹性蛋白酶在急性呼吸窘迫综合征中的研究现状  

Research status of neutrophil elastase in acute respiratory distress syndrome

作　　者：任佳佳 李若寒 金旭婷 高晓明 王岗[1] REN Jia-jia;LI Ruo-han;JIN Xu-ting;GAO Xiao-ming;WANG Gang(Department of Critical Care Medicine,The Second Affiliated Hospital,Xi′an Jiaotong University,Xi′an 710004,China)

机构地区：[1]西安交通大学第二附属医院重症医学科,陕西西安710004

出　　处：《实用医院临床杂志》2024年第4期53-56,共4页Practical Journal of Clinical Medicine

基　　金：陕西省高层次人才特殊支持计划资助项目。

摘　　要：中性粒细胞弹性蛋白酶是中性粒细胞嗜天青颗粒中的主要蛋白酶,在抵御感染中发挥重要作用。然而,大量释放的中性粒细胞弹性蛋白酶可能导致过度炎症反应,加剧肺组织损伤,诱发急性肺损伤/急性呼吸窘迫综合征的发展。西维来司他钠作为一种特异性中性粒细胞弹性蛋白酶抑制剂,在缓解中性粒细胞弹性蛋白酶诱发的病理过程中具有明显的潜力,并在临床急性呼吸窘迫综合征的治疗中受到广泛的关注。本文将深入探讨中性粒细胞弹性蛋白酶的生物学特性及其在急性呼吸窘迫综合征病理生理中的作用机制,以及西维来司他钠在急性呼吸窘迫综合征临床管理中的应用,为深入理解该药物在急性呼吸窘迫综合征治疗中的作用机制提供重要线索。Neutrophil elastase(NE)is the main protease in neutrophil azurophilic granules.It plays a crucial role in combating infections.However,excessive release of NE can trigger an amplified inflammatory response that can exacerbate pulmonary damage,leading to the onset of acute lung injury/acute respiratory distress syndrome(ALI/ARDS).Sivelestat sodium is a specific neutrophil elastase inhibitor.It has obvious potential in the alleviation of neutrophil elastase induced pathological processes.The medicine has also garnered widespread attention in the clinical management of ARDS.This article will deeply explore the biological properties of NE and its mechanism of action in the pathophysiology of ARDS.The application of sivelestat sodium in the clinical management of ARDS is also reviewed.Thus,the important clues for in-depth understanding of the mechanism of action of this drug in the treatment of ARDS would be provided.

关 键 词：急性肺损伤 急性呼吸窘迫综合征 中性粒细胞弹性蛋白酶 凋亡 内皮损伤 

分 类 号：R563.8[医药卫生—呼吸系统]