右美托咪定联合枸橼酸芬太尼注射液对腹腔镜阑尾切除术的镇痛效果  

The Analgesic Effect of Dexmedetomidine Combined with Citrate Fentanyl Injection on Laparoscopic Appendectomy

作　　者：罗花梅 周文荣 LUO Huamei;ZHOU Wenrong(Department of Anesthesiology,People's Hospital of Gao'an,Gao’an 330800,China;不详)

机构地区：[1]高安市人民医院麻醉科,江西高安330800 [2]高安市人民医院骨科,江西高安330800

出　　处：《中国医学创新》2024年第19期62-66,共5页Medical Innovation of China

摘　　要：目的:探究右美托咪定联合枸橼酸芬太尼注射液对腹腔镜阑尾切除术患者的镇痛效果。方法:选取高安市人民医院2022年1月—2023年12月接收的114例腹腔镜阑尾切除术患者,按照随机数字表法分为对照组、观察组,各57例。两组均进行腹腔镜阑尾切除术治疗,对照组接受枸橼酸芬太尼注射液麻醉,观察组接受右美托咪定联合枸橼酸芬太尼注射液麻醉。比较两组生命体征(平均动脉压和心率)、炎症因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、疼痛程度[视觉模拟评分法(VAS)]和舒适度程度[舒适度评分(BCS)]、不良反应发生率。结果:术后6 h,观察组平均动脉压和心率均低于对照组,差异均有统计学意义(P<0.05)。术后24 h,观察组CRP、IL-6、TNF-α水平均低于对照组,差异均有统计学意义(P<0.05)。术后6、12、24、48 h,观察组VAS评分均低于对照组,BCS评分均高于对照组,差异均有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:右美托咪定联合枸橼酸芬太尼注射液能显著优化腹腔镜阑尾切除术后的镇痛管理,提升舒适度,降低炎症反应,未增加不良反应风险。Objective:To explore the analgesic effects of Dexmedetomidine combined with Fentanyl Citrate Injection in patients undergoing laparoscopic appendectomy.Method:A total of 114 patients who underwent laparoscopic appendectomy at People's Hospital of Gao’an from January 2022 to December 2023 were selected as research subjects,they were divided into a control group and an observation group by random number table method,with 57 patients in each group.Both groups underwent laparoscopic appendectomy.The control group received anesthesia with Fentanyl Citrate Injection,while the observation group received anesthesia with Dexmedetomidine combined with Fentanyl Citrate Injection.The postoperative vital signs(mean arterial pressure and heart rate),inflammatory markers[C reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],pain levels[visual analogue scale(VAS)]and comfort levels[bruggrmann comfort score(BCS)],and the incidence of adverse reactions between two groups of patients were compared.Result:Six hours postoperatively,the mean arterial pressure and heart rate in the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).At 24 hours postoperatively,the levels of CRP,IL-6 and TNF-αin the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).At 6,12,24,and 48 hours postoperatively,the VAS scores of the observation group were lower than those of the control group,and the BCS scores were higher,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Dexmedetomidine combined with Fentanyl Citrate Injection can significantly optimize postoperative analgesic management,improve comfort,and reduce inflammatory responses without increasing the risk of adverse reactions.

关 键 词：右美托咪定 枸橼酸芬太尼 腹腔镜阑尾切除术 镇痛效果 不良反应 

分 类 号：R614[医药卫生—麻醉学]