血浆AT-Ⅲ、蛋白C、蛋白S活性对不明原因复发性流产患者妊娠结局的预测价值  

Predictive Value of Plasma AT-Ⅲ,Protein C and Protein S Activity in Pregnancy Outcomes of Patients with Unexplained Recurrent Spontaneous Abortion

作　　者：黄健 HUANG Jian(Laboratory Department,Ganzhou Maternal and Child Health Hospital,Ganzhou 341000,China)

机构地区：[1]赣州市妇幼保健院检验科,江西赣州341000

出　　处：《中国医学创新》2024年第19期127-130,共4页Medical Innovation of China

摘　　要：目的:探讨血浆抗凝血酶Ⅲ(antithrombinⅢ,AT-Ⅲ)、蛋白C(protein C,PC)、蛋白S(protein S,PS)活性对不明原因复发性流产(unexplained recurrent spontaneous abortion,URSA)患者妊娠结局的预测价值。方法:选择2019年8月—2023年8月于赣州市妇幼保健院就诊的80例URSA患者作为研究对象,随访调查80例患者的妊娠结局,将成功分娩患者纳入妊娠结局良好组(n=26),剩余患者纳入妊娠结局不良组(n=54),对比两组血浆AT-Ⅲ、PC、PS活性水平,并采用受试者操作特征(receiver operating characteristic curve,ROC)曲线分析血浆AT-Ⅲ、PC、PS预测URSA患者妊娠结局的价值。结果:妊娠结局不良组血浆AT-Ⅲ、PC、PS水平显著低于妊娠结局良好组,差异均有统计学意义(P<0.05);血浆AT-Ⅲ预测URSA患者不良妊娠结局的AUC为0.820,敏感度为78.75%、特异度为75.71%;PC预测URSA患者不良妊娠结局的AUC为0.892,敏感度为88.75%、特异度为77.14%;PS预测URSA患者不良妊娠结局的AUC为0.838,敏感度为77.50%、特异度为78.57%。结论:URSA后不良妊娠结局患者的血浆AT-Ⅲ、PC、PS活性水平较低,表明机体存在血液高凝状态,可通过早期检测上述指标活性水平,及时进行干预,以改善妊娠结局。Objective:To investigate predictive value of plasma antithrombinⅢ(AT-Ⅲ),protein C(PC),protein S(PS)activity in pregnancy outcomes of patients with unexplained recurrent spontaneous abortion(URSA).Method:A total of 80 patients with URSA who were treated in Ganzhou Maternal and Child Health Hospital from August 2019 to August 2023 were selected as the study objects,and the pregnancy outcomes of 80 patients were followed up and investigated.The patients with successful delivery were included in the good pregnancy outcome group(n=26),and the remaining patients were included in the adverse pregnancy outcome group(n=54).The activity levels of plasma AT-Ⅲ,PC and PS were compared between the two groups,and the value of plasma AT-Ⅲ,PC and PS in predicting pregnancy outcomes of URSA patients was analyzed by receiver operating characteristic(ROC)curve.Result:The plasma levels of AT-Ⅲ,PC and PS in the adverse pregnancy outcome group were significantly lower than those in the good pregnancy outcome group,the differences were statistically significant(P<0.05).The AUC of plasma AT-Ⅲpredicting adverse pregnancy outcomes in URSA patients was 0.820,with a sensitivity of 78.75%and a specificity of 75.71%.The AUC of PC predicting adverse pregnancy outcomes in URSA patients was 0.892,with a sensitivity of 88.75%and a specificity of 77.14%.The AUC of PS predicting adverse pregnancy outcomes in URSA patients was 0.838,with a sensitivity of 77.50%and a specificity of 78.57%.Conclusion:The activity levels of AT-Ⅲ,PC and PS in plasma of patients with adverse pregnancy outcomes after URSA are low,indicating the existence of blood hypercoagulability in the body.Early detection of the activity levels of the above indicators can be carried out in time to improve pregnancy outcomes.

关 键 词：复发性流产 不明原因 妊娠结局 血浆抗凝血因子 蛋白C 蛋白S 活性 预测 

分 类 号：R714.21[医药卫生—妇产科学]