FEV_(1)%pred、FEV_(1)/VC_(max)%在不同年龄哮喘患儿临床诊断中的应用价值  

The Application Value of FEV_(1)%pred and FEV_(1)/VC_(max)%in Clinical Diagnosis of Asthma in Children of Different Ages

作　　者：卫绮燕 宁浩杰[2] 潘志伟[3] 文永钊[3] 廖旺 林丹霞 梁文雅 WEI Qiyan;NING Haojie;PAN Zhiwei;WEN Yongzhao;LIAO Wang;LIN Danxia;LIANG Wenya(Department of Functional Examination,Foshan Women and Children Hospital,Foshan 528000,China;不详)

机构地区：[1]佛山市妇幼保健院功能检查科,广东佛山528000 [2]佛山市妇幼保健院超声科,广东佛山528000 [3]佛山市妇幼保健院儿科,广东佛山528000

出　　处：《中国医学创新》2024年第19期151-155,共5页Medical Innovation of China

基　　金：佛山市卫生健康局医学科研课题(20230229)。

摘　　要：目的:研究FEV_(1)%pred(第1秒用力呼气容积占预测值的百分比)、FEV_(1)/VC_(max)%(第1秒用力呼气体积与最大肺活量的百分比)在不同年龄哮喘患儿临床诊断中的应用价值。方法:选取佛山市妇幼保健院2022年5月—2023年5月就诊的哮喘患儿,并按照年龄阶段不同分为学龄前组(5~6岁)、早学龄组(7~8岁)、中学龄组(9~10岁)、晚学龄组(11~12岁)、青春初期组(13~14岁),各30例,另外选取同期在医院进行体检的健康儿童90例作为学龄前对照组、早学龄对照组、中学龄对照组、晚学龄对照组、青春初期对照组,各18例。检测不同组别患儿的FEV_(1)%pred、FEV_(1)/FVC_(max)%,同时用受试者操作特征(ROC)曲线界定出不同组患儿诊断哮喘的FEV_(1)%pred、FEV_(1)/VC_(max)%的最佳界值,比较不同组FEV_(1)%pred、FEV_(1)/VC_(max)%切点值的敏感度及特异度。结果:五组哮喘患儿FEV_(1)%pred、FEV_(1)/VC_(max)%均低于对照组,差异均有统计学意义(P<0.05);以85.67%、84.11%为界点鉴别诊断在早学龄组患儿FEV_(1)%pred、FEV_(1)/VC_(max)%的AUC值最大,敏感度和特异度分别为83.3%、94.4%及76.7%、94.4%。结论:FEV_(1)%pred和FEV_(1)/VC_(max)%作为哮喘诊断指标,在不同年龄段哮喘患儿中显示出差异化的敏感度和特异度,其最佳切点值能有效指导临床诊断,对早期识别和治疗哮喘具有重要应用价值。Objective:To study the application value of FEV_(1)%pred(percentage of forced expiratory volume in 1 second to the predicted value)and FEV_(1)/VC_(max)%(percentage of forced expiratory volume in 1 second to maximal vital capacity)in the clinical diagnosis of asthma in children of different ages.Method:Asthmatic children who visited Foshan Women and Children Hospital from May 2022 to May 2023 were seclected,they were categorized into different age groups:pre-school age(5-6 years),early school age(7-8 years),middle school age(9-10 years),late school age(11-12 years),and early adolescence(13-14 years),with 30 cases in each group.Additionally,90 healthy children undergoing physical examinations during the same period were selected as the pre-school age control group,early school age control group,middle school age control group,late school age control group,and early adolescence control group,with 18 cases in each group.The FEV_(1)%pred and FEV_(1)/VC_(max)%of children in different groups were measured,and the receiver operating characteristic(ROC)curve was utilized to establish the optimal threshold values of FEV_(1)%pred,FEV_(1)/VC_(max)%for diagnosing asthma in different groups.The sensitivity and specificity of the FEV_(1)%pred and FEV_(1)/VC_(max)%cutoff values were compared across groups.Result:The FEV_(1)%pred and FEV_(1)/VC_(max)%values in all five groups of asthmatic children were significantly lower than those in the control group,the differences were statistically significant(P<0.05).The AUC area of FEV_(1)%pred and FEV_(1)/VC_(max)%were the largest in the early school age group with 85.67%and 84.11%as the cut-off points,and the sensitivity and specificity were 83.3%,94.4%and 76.7%,94.4%,respectively.Conclusion:FEV_(1)%pred and FEV_(1)/VC_(max)%,as diagnostic indicators for asthma,demonstrate varied sensitivity and specificity among asthmatic children of different ages.Their optimal cut-off values can effectively guide clinical diagnosis and are of significant value in the early identification and treatmen

关 键 词：FEV_(1)%pred FEV_(1)/VC_(max)% 哮喘 儿童 不同年龄阶段 

分 类 号：R725.6[医药卫生—儿科]