维生素D辅助治疗危重症疾病的作用机制及研究进展  

Mechanism and Research Progress of Vitamin D Adjuvant Therapy for Critical Illness

作　　者：宋会杰 王玉[1] 吴方方[1] 杜帆帆 SONG Huijie;WANG Yu;WU Fangfang;DU Fanfan(Department of Pediatrics,People's Hospital of Henan University,Zhengzhou 450003,China;不详)

机构地区：[1]河南大学人民医院(河南省人民医院)儿科,河南郑州450003

出　　处：《中国医学创新》2024年第19期178-184,共7页Medical Innovation of China

基　　金：河南省医学科技攻关计划省部共建项目(SBGJ202102018)。

摘　　要：危重症疾病往往伴随着全身炎症反应综合征,此期间活性氧及一氧化氮等氧化产物增加,而抗氧化剂浓度降低。失衡的氧化应激反应可导致细胞、组织和器官损伤,增加危重患者的死亡率。维生素D(VD)作为人体新陈代谢所必需的营养物质,在诸多生理过程中发挥着重要作用,而且VD在辅助治疗危重症疾病方面的作用也不容忽视。最近研究表明,补充VD可有效改善危重症患者的预后,是辅助治疗危重症疾病颇具潜力的手段之一。本文现对VD在危重症疾病治疗中的相关文献进行总结,希望能对进一步提高危重症疾病预后提供帮助。Critical illness is often accompanied by systemic inflammatory response syndrome.During this period,oxidative products such as reactive oxygen species and nitric oxide increase,while the concentration of protective antioxidants decreases.Imbalanced oxidative stress can lead to cell,tissue and organ damage and increase the mortality of critically ill patients.As an essential nutrient for human metabolism,vitamin D(VD)plays an important role in many physiological processes,and the role of VD in the adjuvant treatment of critically illness cannot be ignored.Recent studies have shown that VD supplementation can effectively improve the prognosis of critically ill patients and is one of the potential means for adjuvant treatment of critically illness.In this paper,the related literature of VD in the treatment of critical illness is summarized,hoping to provide help for further improving the prognosis of critical illness.

关 键 词：危重症 维生素D 预后 

分 类 号：R459.7[医药卫生—急诊医学]