2023年宁夏回族自治区健康人群脑膜炎奈瑟菌携带状况调查  

Neisseria meningitidis carriage in healthy people in Ningxia Hui Autonomous Region:a cross-sectional survey in 2023

作　　者：肖琳 孙伟[1,2] 李娜[2] 杨丽娟[2] 郭邦成 Xiao Lin;Sun Wei;Li Na;Yang Lijuan;Guo Bangcheng(Ningxia Medical University,Yinchuan 750004,Ningxia,China;Ningxia Hui Autonomous Region Center for Disease Control and Prevention,Yinchuan 750001,Ningxia,China)

机构地区：[1]宁夏医科大学,宁夏银川750004 [2]宁夏回族自治区疾病预防控制中心,宁夏银川750001

出　　处：《中国疫苗和免疫》2024年第3期283-287,共5页Chinese Journal of Vaccines and Immunization

基　　金：2023年宁夏自然科学基金项目(2023AAC03715)。

摘　　要：目的了解宁夏回族自治区健康人群脑膜炎奈瑟菌(Neisseria meningitidis,Nm)携带状况。方法采用分层随机抽样方法在宁夏5个市10个县选择健康人群采集咽拭子样本,检测Nm核酸并鉴定血清群,分析Nm核酸检测阳性率和血清群构成。结果调查对象Nm核酸检测总阳性率为3.53%(42/1190),其中0-6岁、7-13岁、14-19岁、20-39岁、≥40岁阳性率分别为3.91%、4.42%、5.21%、0.48%、3.70%,5个市阳性率在0.36%-9.72%之间。在42株Nm菌株中,B群、C群、Y群和W135群Nm分别占4.76%(2株)、35.71%(15株)、4.76%(2株)、54.76%(23株)。结论2023年宁夏调查地区健康人群Nm带菌率低,以中学生群体带菌为主,优势Nm血清群为W135群和C群。建议加强适龄人群脑膜炎球菌疫苗接种,优化流行性脑脊髓膜炎免疫预防策略。Objective To explore Neisseria meningitidis(Nm)carriage in a healthy population in Ningxia Hui Autonomous Region.Methods We used stratified random sampling to obtain throat swab samples from healthy individuals in 10 counties of 5 prefectures in Ningxia.We tested for Nm nucleic acid and identified serogroups to determine Nm nucleic acid positive rates and serogroup distributions.Results The overall Nm nucleic acid positivity rate was 3.53%(42/1190).Positivity rates for 0-6-,7-13-,14-19-,20-39-,and≥40-year-olds were 3.91%,4.42%,5.21%,0.48%,and 3.70%,respectively,ranging from 0.36%to 9.72%by prefecture.Among 42 Nm strains,serogroup B,C,Y,and W135 accounted for 4.76%(2 strains),35.71%(15 strains),4.76%(2 strains),and 54.76%(23 strains).Conclusions Nm carriage was low among a healthy population in Ningxia,but with higher carriage in secondary school students.The predominant Nm serogroups were W135 and C.We suggest strengthening meningococcal vaccination in age-eligible populations and optimizing immunization strategies for meningococcal disease.

关 键 词：脑膜炎奈瑟菌 血清群 携带 健康人群 

分 类 号：R515.2[医药卫生—内科学] R181.3[医药卫生—临床医学]