宁波市2011-2016年出生儿童水痘突破病例流行病学特征  

Epidemiological characteristics of breakthrough varicella among children born during 2011-2016 in Ningbo city

作　　者：潘兴强[1] 张丹丹[1] 马瑞[1] 杨天池[1] 童峰 Pan Xingqiang;Zhang Dandan;Ma Rui;Yang Tianchi;Tong Feng(Ningbo Municipal Center for Disease Control and Prevention,Ningbo 315000,Zhejiang,China)

机构地区：[1]宁波市疾病预防控制中心,浙江宁波315000

出　　处：《中国疫苗和免疫》2024年第3期303-306,共4页Chinese Journal of Vaccines and Immunization

基　　金：浙江省医药卫生科技计划(2023KY1130);宁波市科技计划项目(2023S042);宁波市医疗卫生高端团队重大攻坚项目(2023020713)。

摘　　要：目的分析宁波市儿童水痘突破病例流行病学特征。方法通过宁波市儿童预防接种信息系统和中国疾病预防控制信息系统记录匹配,纳入宁波市2011-2016年出生儿童接种水痘疫苗(Varicella vaccine,VarV)后截至2020年12月31日发病的水痘突破病例,比较1剂次和2剂次VarV接种儿童水痘突破病例报告发病率。结果宁波市2011-2016年出生儿童水痘突破病例总报告发病率为142.86/10万(920例);其中接种1剂次、2剂次VarV儿童分别为590.82/10万(520例)、71.94/10万(400例),平均发病年龄分别为3.63±2.01岁、6.30±1.60岁,累计发病率分别从接种后第18个月的11.53/10万、4.79/10万快速上升至第36个月的140.00/10万、58.76/10万。结论宁波市儿童水痘突破病例发病率随着VarV接种时间的推移呈上升趋势,接种2剂次VarV显著降低了水痘突破病例发病率。Objective To analyze epidemiological characteristics of breakthrough varicella in Ningbo children.Methods We enrolled children born during 2011-2016 who had varicella breakthrough infections after receiving varicella vaccine(VarV)that occurred on or before December 31,2020.We used case records from the China Disease Control and Prevention Information System matched with vaccination records from the Ningbo Children's Vaccination Information System.We compared reporting incidences of breakthrough varicella for 1-dose and 2-dose VarV vaccination.Results The overall incidence of reported breakthrough varicella was 142.86 per 100000 population(920 cases).Incidences per 100000 for 1-dose and 2-dose VarV were 590.82(520 cases)and 71.94(400 cases),respectively,with average ages of onset of 3.63±2.01 and 6.30±1.60 years.Cumulative incidences per 100000 increased rapidly from 11.53 and 4.79 at 18 months to 140.00 and 58.76 at 36 months after 1-dose and 2-dose vaccination.Conclusions The incidence of breakthrough varicella among Ningbo children increased over time after VarV vaccination;2-dose VarV vaccination significantly reduced breakthrough incidence.

关 键 词：水痘 水痘疫苗 疫苗接种 水痘突破病例 流行病学特征 

分 类 号：R186[医药卫生—流行病学] R181.3[医药卫生—公共卫生与预防医学]