复荣通脉胶囊联合利拉鲁肽治疗2型糖尿病临床观察  

Clinical Observation of Furong Tongmai Capsules Combined with Liraglutide in the Treatment of Diabetes Mellitus Type 2

作　　者：马艳霞 田风胜[1] 崔荣岗[1] 刘燕 孟莹莹 王凤英 MA Yanxia;TIAN Fengsheng;CUI Ronggang;LIU Yan;MENG Yingying;WANG Fengying(Cangzhou Hospital of Integrated TCM-WM,Cangzhou,Hebei,China 061000)

机构地区：[1]河北省沧州中西医结合医院,河北沧州061000

出　　处：《中国药业》2024年第14期99-101,共3页China Pharmaceuticals

基　　金：河北省中医药管理局科研计划项目[2022249]。

摘　　要：目的 探讨复荣通脉胶囊联合利拉鲁肽对2型糖尿病(T2DM)患者的血糖相关指标、颈动脉粥样硬化斑块面积及纤维蛋白原(Fib)水平的影响。方法 选取医院2021年1月至2022年12月收治的T2DM患者90例,按随机数字表法分为观察组和对照组,各45例。两组患者均予利拉鲁肽注射液皮下注射,观察组患者加服复荣通脉胶囊。两组均连续用药3个月。结果 治疗后,两组患者的中医证候积分、空腹血糖、餐后2 h血糖、糖化血红蛋白、Fib水平均显著降低,且观察组显著低于对照组(P <0.05);两组患者颈动脉粥样硬化斑块面积均显著缩小,且观察组显著小于对照组(P <0.05)。观察组不良反应发生率显著低于对照组(8.89%比24.44%,P <0.05)。结论 复荣通脉胶囊联合利拉鲁肽治疗T2DM,可有效降低患者的血糖指标水平,改善中医证候及凝血功能,减轻颈动脉粥样硬化程度。Objective To investigate the effects of Furong Tongmai Capsules combined with liraglutide on the blood glucose-related indexes,carotid atherosclerotic plaque area and fibrinogen(Fib)level in patients with diabetes mellitus type 2(T2DM).Methods A total of 90 patients with T2DM admitted to the hospital from January 2021 to December 2022 were selected and divided into the observation group and the control group by the random number table method,with 45 cases in each group.The patients in the two groups were given subcutaneous injection of Liraglutide Injection,on this basis,the patients in the observation group were given Furong Tongmai Capsules.Both groups were treated continuously for three months.Results After treatment,the traditional Chinese medicine(TCM)syndrome score,fasting blood glucose(FBG),2-hour postprandial blood glucose(2 hPG),glycosylated hemoglobin(HbA1C)and Fib levels in the two groups significantly decreased(P<0.05),and those in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the carotid atherosclerotic plaque area in the two groups significantly decreased(P<0.05),and that in the observation group was significantly smaller than that in the control group(P<0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(8.89%vs.24.44%,P<0.05).Conclusion Furong Tongmai Capsules combined with liraglutide can effectively decrease the blood glucose-related index levels,improve TCM syndromes and blood coagulation function,and relieve the carotid atherosclerosis in patients with T2DM.

关 键 词：复荣通脉胶囊 利拉鲁肽 2型糖尿病 颈动脉粥样硬化 血糖 纤维蛋白原 中医证候 

分 类 号：R969.4[医药卫生—药理学] R587.1[医药卫生—药学]