Aging-induced memory loss due to decreased N1-acetyl-5-methoxykynuramine,a melatonin metabolite,in the hippocampus:a potential prophylactic agent for dementia  

作　　者：Kazuki Watanabe Atsuhiko Hattori 

机构地区：[1]Department of Immunobiology,Institute of Development Aging and Cancer,Tohoku University,Sendai,Miyagi,Japan [2]Department of Sport and Wellness,College of Sport and Wellness,Rikkyo University,Niiza,Saitama,Japan

出　　处：《Neural Regeneration Research》2025年第6期1705-1706,共2页中国神经再生研究（英文版）

基　　金：supported by JSPS KAKENHI Grant Number JP22K11823 to AH and JP22J01508 to KW。

摘　　要：Melatonin(N-acetyl-5-methoxytryptamine)is known as the hormone of darkness because it is synthesized at night and involved in regulating the circadian clock.The hormone is primarily synthesized by the vertebrate pineal gland,but is ubiquitous among invertebrates,unicellular organisms,plants,and even cyanobacteria(Hattori and Suzuki,2024).Melatonin is well-conserved evolutionarily and possesses several physiological functions,such as immune response,bone and glucose metabolism,and memory formation besides regulating the circadian rhythm.

关 键 词：metabolism primarily AGENT 

分 类 号：R338.64[医药卫生—人体生理学]